Naslov
Dog mastocytoma and mammary tumors fatty acid profile: possible implications for tumor grading and prognosis

Autori
Mašek, Tomislav ; Severin, Krešimir ; Šoštarić-Zuckermann, Ivan-Conrado ; Maurić, Maja ; Musulin, Andrija ; Vnuk, Dražen ; Vince, Silvijo ; Ljolje, Ivana ; Ćirić, Žarko ; Džaja, Petar ; Starčević, Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
43rd World small animal veterinary association congress and 9th FASAVA congress, Program book / - Singapur, 2018, 208-208

Skup
43rd WSAVA Congress and 9th FASAVA Congress

Mjesto i datum
Singapur, Singapur, 25.09.2018. - 28.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Dog, Tumor, Fatty acids, Tumor grading

Sažetak
Introduction: Lipid metabolism has been accepted as a major metabolic pathway that is involved in many aspects of cancer cell pathogenesis. Attempts to understand the role of different lipids in cancer physiology depend on the ability to accurately monitor alterations in lipid composition at cell level due to the diversity of lipid classes. Objectives: Mastocytoma and mammary gland tumor are common tumors in pet veterinary medicine. We investigated the differences in fatty acid profile of tumor and normal tissue sample in attempt to get better insight into the lipid metabolism of tumor cells as well as to improve grading of studied tumors. Methods: Paired samples of tumor and adjacent non-tumor tissue were isolated from 21 mastocytoma and 37 mammary tumors. After the pathohistological examination of tumor and non-tumor samples, fatty acid profile was determined by GC-MS. Results: All tumors showed significant difference compared to the normal tissue. The most significant difference were the increased content in C20:4n6 in both tumors, the increased content in 18:0, 18:1n9, 22:4n6 and 22:5n3 for mastocytoma and the increased content of 18:1n7, 20:3n6, C22:4n6 and C22:5n6 for the mammary tumors. Conclusion: These preliminary results showed significant variations in fatty acid profile between tumor and non-tumor tissue as well as within tumor tissues depending on tumor type. Further researches should address the correlation between alterations in the fatty acid profile of different lipid classes and tumor prognosis.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA