Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 958331

Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule


Zhang, Issan; Beus, Maja; Stochaj, Ursula; Le, Phuong, Uyen; Zorc, Branka; Rajić, Zrinka; Petrecca, Kevin; Maysinger, Dusica
Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule // Cell death discovery, 4 (2018), 41, 14 doi:10.1038/s41420-018-0103-0 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 958331 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule

Autori
Zhang, Issan ; Beus, Maja ; Stochaj, Ursula ; Le, Phuong, Uyen ; Zorc, Branka ; Rajić, Zrinka ; Petrecca, Kevin ; Maysinger, Dusica

Izvornik
Cell death discovery (2058-7716) 4 (2018); 41, 14

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
glioblastoma ; hybrid molecule ; histone deacetylase inhibitor

Sažetak
Glioblastoma multiforme is one of the most aggressive brain tumors and current therapies with temozolomide or suberoylanilide hydroxamic acid (SAHA, vorinostat) show considerable limitations. SAHA is a histone deacetylase (HDAC) inhibitor that can cause undesirable side effects due to the lack of selectivity. We show here properties of a novel hybrid molecule, sahaquine, which selectively inhibits cytoplasmic HDAC6 at nanomolar concentrations without markedly suppressing class I HDACs. Inhibition of HDAC6 leads to significant α- tubulin acetylation, thereby impairing cytoskeletal organization in glioblastoma cells. The primaquine moiety of sahaquine reduced the activity of Pglycoprotein, which contributes to glioblastoma multiforme drug resistance. We propose the mechanism of action of sahaquine to implicate HDAC6 inhibition together with suppression of epidermal growth factor receptor and downstream kinase activity, which are prominent therapeutic targets in glioblastoma multiforme. Sahaquine significantly reduces the viability and invasiveness of glioblastoma tumoroids, as well as brain tumor stem cells, which are key to tumor survival and recurrence. These effects are augmented with the combination of sahaquine with temozolomide, the natural compound quercetin or buthionine sulfoximine, an inhibitor of glutathione biosynthesis. Thus, a combination of agents disrupting glioblastoma and brain tumor stem cell homeostasis provides an effective anti–cancer intervention

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Zrinka Rajić (autor)

Avatar Url Branka Zorc (autor)

Avatar Url Maja Beus (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Zhang, Issan; Beus, Maja; Stochaj, Ursula; Le, Phuong, Uyen; Zorc, Branka; Rajić, Zrinka; Petrecca, Kevin; Maysinger, Dusica
Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule // Cell death discovery, 4 (2018), 41, 14 doi:10.1038/s41420-018-0103-0 (međunarodna recenzija, članak, znanstveni)
Zhang, I., Beus, M., Stochaj, U., Le, Phuong, Uyen, Zorc, B., Rajić, Z., Petrecca, K. & Maysinger, D. (2018) Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule. Cell death discovery, 4, 41, 14 doi:10.1038/s41420-018-0103-0.
@article{article, author = {Zhang, Issan and Beus, Maja and Stochaj, Ursula and Zorc, Branka and Raji\'{c}, Zrinka and Petrecca, Kevin and Maysinger, Dusica}, year = {2018}, pages = {14}, DOI = {10.1038/s41420-018-0103-0}, chapter = {41}, keywords = {glioblastoma, hybrid molecule, histone deacetylase inhibitor}, journal = {Cell death discovery}, doi = {10.1038/s41420-018-0103-0}, volume = {4}, issn = {2058-7716}, title = {Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule}, keyword = {glioblastoma, hybrid molecule, histone deacetylase inhibitor}, chapternumber = {41} }
@article{article, author = {Zhang, Issan and Beus, Maja and Stochaj, Ursula and Zorc, Branka and Raji\'{c}, Zrinka and Petrecca, Kevin and Maysinger, Dusica}, year = {2018}, pages = {14}, DOI = {10.1038/s41420-018-0103-0}, chapter = {41}, keywords = {glioblastoma, hybrid molecule, histone deacetylase inhibitor}, journal = {Cell death discovery}, doi = {10.1038/s41420-018-0103-0}, volume = {4}, issn = {2058-7716}, title = {Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule}, keyword = {glioblastoma, hybrid molecule, histone deacetylase inhibitor}, chapternumber = {41} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font