Pregled bibliografske jedinice broj: 957478
Impact of cyclodextrin encapsulation on in vitro bioavailability of hydroxytyrosol and tyrosol from olive pomace extract
Impact of cyclodextrin encapsulation on in vitro bioavailability of hydroxytyrosol and tyrosol from olive pomace extract // Bioavailability 2018 - Understanding the bioavailability of micronutrients and bioactive compounds for improved public health
Norwich, Ujedinjeno Kraljevstvo, 2018. str. 53-53 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 957478 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Impact of cyclodextrin encapsulation on in vitro bioavailability of hydroxytyrosol and tyrosol from olive pomace extract
Autori
Jurmanović, Sanja ; Jurišić Dukovski, Bisera ; Jug, Mario ; Lovrić, Jasmina ; Radić, Kristina ; Vitali Čepo, Dubravka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Bioavailability 2018 - Understanding the bioavailability of micronutrients and bioactive compounds for improved public health
/ - , 2018, 53-53
Skup
Bioavailability 2018: Understanding the bioavailability of micronutrients and bioactive compounds for improved public health
Mjesto i datum
Norwich, Ujedinjeno Kraljevstvo, 10.09.2018. - 13.09.2018
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
hydroxytyrosol, tyrosol, in vitro bioavailability, olive pomace
Sažetak
Due to their proven health-promoting properties, increasing efforts are being made to find sustainable and efficient ways to extract polyphenols from olive pomace and formulate them into stable products. Namely, their further utilization is often limited by inadequate physicochemical properties, extensive degradation during storage or low bioavailability. Some of these limitations can be successfully overcome by utilization of encapsulated polyphenols, instead of free compounds. The aim of this study was to investigate the impact of cyclodextrin encapsulation used for preparation of stable and organoleptically acceptable dry olive pomace extracts, on in vitro bioavailability of hydroxytyrosol and tyrosol from obtained formulations. Microencapsulation was achieved by freeze-drying of olive pomace extracts with different types of cyclodextrins (CDs): βCD, randomly methylated βCD, hydroxypropyl β-CD, and γ-CD. Gastrointestinal stability and bioavailability of encapsulated antioxidants were investigated by two in vitro approaches: dializability and Caco-2-cell permeability. Content of hidroxytyrosol and tyrosol in different sample fractions obtained during simulation of gastrointestinal digestion was compared to results obtained by analysing the gastrointestinal stability of native formulation (N) prepared without the addition of cyclodextrins. During gastric phase, the content of tyrosol was significantly reduced (51-64%) while the content of hydroxytyrosol significantly increased, probably as the result of gastric degradation of other complex polyphenolic compounds resulting with hydroxytyrosol formation. Their content remained relatively unchanged during the intestinal phase of digestion. Significant correlation was obtained between dializability and transephitelial permeability of both, hydroxytyrosol and tyrosol. Both parameters were negatively influenced by the presence of CDs in the formulation, possibly due to formation of cyclodextrin aggregates that may occur under the simulated conditions of small intestine. Among investigated cyclodextrins, γ- CD showed the least negative effect on dializability and transephitelial permeability of hydroxytyrosol and tyrosol, reducing them by 15% on average, in comparison to native sample.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
POVEZANOST RADA
Projekti:
HRZZ-UIP-2014-09-9143 - Održivi razvoj inovacije u hrani - valorizacija otpada masline (NutriOliWa) (Vitali Čepo, Dubravka, HRZZ - 2014-09) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
Profili:
Bisera Jurišić
(autor)
Dubravka Vitali Čepo
(autor)
Mario Jug
(autor)
Sanja Jurmanović
(autor)
Kristina Radić
(autor)
Jasmina Lovrić
(autor)