Naslov
The Effectiveness of Icariin on Biomarkers for Osteoporosis

Autori
Oršolić, Nada ; Nemrava, Johann ; Odeh, Dyana ; Kukolj, Marina ; Lesar, Nikola ; Lovrić, Ivana ; Jeleč, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th Croatian Biological Congress with International Participation: book of abstracts / - , 2018, 290-291

Skup
13. Hrvatski biološki kongres

Mjesto i datum
Poreč, Hrvatska, 19.09.2018. - 23.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Icariin ; retinoic acid-induced bone loss ; rats ; bone markers

Sažetak
Nutrition is important factor that influence bone metabolism, the endocrine and/or paracrine system, and bone-active mineral elements homeostasis. We studied antiosteoporetic effects of icariin and alendronate (ALN) in retinoic acid-induced (13cRA) bone loss in rats. Icariin has beneficial effects on bone health ; it improved the decrease in bone weight, the length and the diameter of the bone, calcium, and phosphorus content in bone ash, bone mineral density (BMD) and the biochemical markers of bone turnover and uterus atrophy induced by 13cRA. All result suggests that icariin reverses osteoporosis in 13cRA rats by stimulating bone formation or regulating bone resorption by its antioxidative and estrogenic-like activity without toxic-side effect observed in ALN treatment.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti

POVEZANOST RADA