Naslov
Effects of aluminum chloride on lipid peroxidation and distribution of toxic and essential/trace elements in rats liver and spleen tissues

Autori
Kukolj, Marina ; Oršolić, Nada ; Odeh, Dyana ; Orct, Tatjana ; Šimić, Goran ; Horvat Langer, Lea ; Šoštarić, Branko ; Branović Čakanić, Karmen ; Grabarević, Dunja ; Terzić, Svjetlana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th Croatian Biological Congress with International Participation: book of abstracts / Kružić, Petar ; Caput Mihalić, Katarina ; Gottstein, Sanja ; Pavoković, Dubravko ; Kučinić, Mladen - , 2018, 330-331

Skup
13th Croatian Biological Congress with International Participation

Mjesto i datum
Poreč, Hrvatska, 19.09.2018. - 29.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
aluminum chloride ; toxic elements ; essential elements ; detoxification

Sažetak
Aluminum (Al) is a nonessential, toxic element which is assoiated with number of disorders in people (e.g. Alzheimer's disease). While, hematopoietic organs (liver and spleen) are the vital sites involved in detoxification. This study was aimed to explore antioxidative and detoxifying capacity of the liver and spleen after administration of aluminum chloride. Twelve male Y59 rats were intraperitoneally administered with: (a) 0, 9% NaCl (control group) and (b) AlCl3 (10 mg/kg) and D-(+)- galactose (60 mg/kg) per day consecutively for 28 days. The analysis of essential and toxic elements in the liver and spleen tissues was performed by mass spectrometry inductively coupled plasma (ICP-MS). Lipid peroxidation (LP) was measured by thiobarbituric acid assay in homogenates of liver and spleen. The results showed statistically significant increase of toxic metals (Al, Cd, As) in liver and spleen tissues, also essential/trace elements in liver (Co, Sr, Mo P, S, Ca, Fe, Cu, Zn, Se, Na, Mg) and spleen (Mo, Ca, Fe, Se) tissues of rats treated with AlCl3 compared to the control group. While P, S, Mn, Zn, Mg in the spleen was significantly reduced. The level of LP was significantly increased in spleen tissues of AlCl3-treated rats. The results indicate that AlCl3 interfere with the metabolic function of the liver and leads to disruption of trace element, while spleen has less changes in the essential elements but higher sensibility to proxidative effect of AlCl3.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kemijsko inženjerstvo, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA