Naslov
Enhanced release of the antioxidant flavonols induced by magnetic field of very low frequency

Autori
Mustapić, Mislav ; Šegota, Suzana ; Baranović, Goran ; Čadež, Vida ; Stojaković, Elizabeta ; Domazet Jurašin, Darija ; Crnolatac, Ivo ; Dutour Sikirić, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, ostalo, znanstveni

Skup
ECIS 2018

Mjesto i datum
Ljubljana, Slovenija, 02.09.2018. - 07.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
magnetic aggregates, enhanced release, magnetic field

Sažetak
Due to their specific porous structure and superparamagnetic property, mesoporous aggregates (MAs) could allow physical delivering of drugs to the desired target area through the influences of an external magnetic field [1]. Thus, the total drug concentration administered into an organism is reduced drastically and side effects are avoided. Intention was to use the flavonol loaded agglomerates of magnetite nanoparticles as vectors that can be directed by means of magnetic field gradient towards a certain location. Loading of poorly soluble, hydrophobic flavonols (quercetin, myricetin and myricitrin) onto mesoporous aggregates comprised of uncoated magnetite nanoparticles and their release under the influence of permanent and/or alternating magnetic field was investigated [2]. Besides low toxicity due to the lack of nanoparticle coatings the investigated mesoporous structures are shown to possess an advantageous feature of high loading efficiency of flavonols [3]. In addition to electrostatic interaction between hydroxyl groups at the surface of the Fe3O4 MAs, governing the initial stages of drug loading, the interactions between flavonol molecules contribute to high loading efficiency. The stabilization is considered crucial especially in biological applications. However, if the idea is to bring unusually high quantity of flavonol into the intestinal tract the use of flavonol loaded agglomerates seems reasonable. This study confirmed that the mesoporous Fe3O4 structures presents an universal, stable and excellent drug delivery material particularly able to load and release with high efficiency flavonols of different physico-chemical and/or structural properties. The fine-tuning of their drug release by means of weak external magnetic field oscillating with very low frequency was demonstrated indicating the high potential of mesoporous material as drug carriers.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Biotehnologija

POVEZANOST RADA