Naslov
Salivary malondialdehyde – a biomarker of oxidative stress

Autori
Alajbeg, Iva ; Vrbanović, Ema ; Rogić, Dunja ; Lapić, Ivana ; Vuletić, Lea ; Andabak Rogulj, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 3rd International Congress of the School of DentalMedicine, University of Zagreb, u Acta stomatologica Croatica, 51, 3, 2017, 249-264. / Tarle, Zrinka - Zagreb, 2017, 251-252

Skup
3rd International Congress of the School of Dental Medicine, University of Zagreb

Mjesto i datum
Zagreb, Hrvatska, 03.03.2017. - 04.03.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
oxidative stress ; unstimulated saliva ; inter-day variations ; malodialdehyde

Sažetak
Aim: Malondialdehyde (MDA) is marker of oxidative stress and one of the many reactive electrophiles that can cause toxic stress that leads to changes of human cells. Thereby MDA can act as a cofactor in the formation of many oral diseases. Little data exist for salivary oxidative stress markers in the healthy population. The aim of the study was to evaluate of the variability of salivary MDA in healthy individuals during 3 consecutive days, and to observe the influence of the time of day on the levels of salivary MDA. Method: Whole unstimulated saliva samples were collected from 15 healthy adults twice daily on three consecutive days Markers were measured using spectrophotometric method. Results: No significant differences for MDA levels were observed between men and women (p>0.05). Mean MDA values ranged from 313.92 pmol/mL in the morning to 527.95 pmol/mL in the afternoon. Repeated measures ANOVA did not show the significant influence of sampling day as a factor affecting the MDA variability (p>0.05). Time of a day as a factor affecting variability was found to be statistically significant (F=6.486, p=0.024). MDA showed high inter- individual variability of 71.9%. The between- day repeatability was found to be 0.691 for morning and 0.796 for afternoon MDA. Conclusion: Wide variations were observed for salivary MDA concentrations in healthy adult subjects which is in accordance with current research. While controlling for time of a day, salivary MDA can be measured reliably over time since the between-day repeatability of measurements was acceptable.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA