Naslov
Salivary cortisol and antioxidan levels in patients with chronic temporomanidbular disorders

Autori
Vrbanović, Ema ; Lapić, Ivana ; Rogić, Dunja ; Alajbeg, Iva

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Abstracts of the 4th International Congress of the School of Dental Medicine, University of Zagreb ; in Acta stomatologica Croatica, Vol. 52 No. 2 / Tarle, Zrinka ; Klarić, Eva - Zagreb, 2018, 162-171

Skup
4. međunaroddni kongres Stomatološkog fakulteta Sveučilišta u Zagrebu

Mjesto i datum
Zagreb, Hrvatska, 02.03.2018. - 03.03.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
temporomandibular disorders ; oxidative stress ; salivary diagnostics ; antioxidants ; salivary cortisol

Sažetak
Aim: Risk factors associated with temporomandibular disorders (TMD) include mechanical and psychological stressors that increase the likelihood of developing and maintaining a chronic pathologic state. The aim of this study was to investigate the relationship between salivary antioxidant parameters, salivary cortisol and TMD. Materials and Methods: In total, 12 patients, who were diagnosed with chronic TMD, and 15 systemically and periodontally healthy individuals were included. Five milliliters of whole unstimulated saliva was collected into a graduated tube at 2 time intervals, 7 AM and 5 PM. Salivary anti-oxidant enzymes (superoxide dismutase (SOD), and glutathione peroxidase (GPx)), total antioxidant capacity (TAC) and uric acid (UA) were analyzed using spectrophotometric methods. Salivary cortisol was determined by enzyme-linked immunosorbent assay (ELISA). T- test was used to compare salivary biomarker levels between patients with TMD and the control group. Pearson’s correlation analysis was used to study the correlation among antioxidants and salivary cortisol levels. P< 0.05 was considered significant. Results: No significant difference in age between groups was found (p>0.05). Significant differences in the mean salivary levels of SOD (p<0.001) between the groups were found whereas the mean salivary levels of cortisol, GPx, TAC and UA were higher in the TMD group but without statistical significance. There was a highly significant positive correlation (p<0.05) between salivary cortisol levels and antioxidant parameters in TMD patients. Conclusion: Previous studies showed lower levels of anti-oxidant enzymes in TMD patients indicating that anti- oxidant defense is lowered in these patients. Higher levels of antioxidants in TMD patients, as compared to healthy controls, obtained in our study, could represent compensatory increase as a result of potentially higher level of stress.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA