Naslov
The Influence of Diabetes and Metabolic Syndrome on Liver Fatty Acid Profile: What can we Learn from Animal Models

Autori
Mašek, Tomislav

Izvornik
CPQ Nutrition

Vrsta, podvrsta
Ostale vrste radova, ostalo

Godina
2018

Ključne riječi
diabetes ; fatty acids

Sažetak
Whole body fatty acids can originate from three different sources: food, de novo lipogenesis and bioconversion. Fatty acids generated de novo, as well as fatty acids derived from food can be bioconverted to longer-chain fatty acids with more carbon atoms and/or double bonds, by a series of steps of desaturation and elongation, or shortened by β-oxidation steps and recycled between peroxisomes and the endoplasmatic reticulum. Regulation of these steps involves desaturases (Δ9D, Δ6D, Δ5D) and elongases (Elovl2, Elovl5 and Elovl6), as well as different metabolites (glucose), hormones (insulin) and transcriptional factors (peroxisome proliferator-activated receptors α, PPARα ; sterol response element- binding protein-1c, SREBP-1c ; liver X receptor, LXR ; carbohydrate-regulatory element binding protein, ChREBP ; MAX-like factor X, MLX) and microRNA. Nutrition (substrate availability) and competition for rate-limiting enzymes for desaturation, as well as partitioning into oxidation could substantially contribute or even override other regulatory mechanisms.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA