Pregled bibliografske jedinice broj: 954997
Sahaquine: a novel hybrid molecule for glioblastoma multiforme
Sahaquine: a novel hybrid molecule for glioblastoma multiforme // 24th Annual Pharmacological Research Day
Montréal: McGill, 2018. str. 43-43 (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 954997 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Sahaquine: a novel hybrid molecule for glioblastoma multiforme
Autori
Zhang, Issan ; Beus, Maja ; Stochaj, Ursula ; Zorc, Branka ; Maysinger, Dusica
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
24th Annual Pharmacological Research Day
/ - Montréal : McGill, 2018, 43-43
Skup
24th Annual Pharmacological Research Day
Mjesto i datum
Montréal, Kanada, 14.09.2018
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
hybrid molecule ; glioblastoma ; histone deacetylase 6
Sažetak
Glioblastoma multiforme (GBM) is the most common and deadly of brain tumors. Current chemotherapy with temozolomide shows considerable limitations in primary GBM and is largely ineffective in recurrent tumors. Histone deacetylase 6 (HDAC6) has emerged as a valuable target in cancer, as it promotes tumorigenesis, tumor survival and invasiveness. Pan- HDAC inhibitors (e.g. vorinostat) have been investigated in clinical trials for GBM but caused serious side effects due to a lack of selectivity. We present here the mechanisms of action of sahaquine, a novel hybrid molecule that selectively inhibits histone deacetylase 6 (HDAC6), which is highly upregulated in GBM compared to normal brain tissues.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija
POVEZANOST RADA
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
