Pregled bibliografske jedinice broj: 953942
The effect of oral galactose on glucose homeostasis and memory in a transgenic mice model of familial Alzheimer's disease
The effect of oral galactose on glucose homeostasis and memory in a transgenic mice model of familial Alzheimer's disease // 11th FENS Forum of Neuroscience Abstracts
Berlin, Njemačka, 2018. str. 4102-4102 (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 953942 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The effect of oral galactose on glucose homeostasis and memory in a transgenic mice model of familial Alzheimer's disease
Autori
Babić, Ana ; Osmanović Barilar, Jelena ; Knezović, Ana ; Bagarić, Robert ; Farkaš, Vladimir ; Riederer, Peter ; Šalković-Petrišić, Melita
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
11th FENS Forum of Neuroscience Abstracts
/ - , 2018, 4102-4102
Skup
11th FENS Forum of Neuroscience
Mjesto i datum
Berlin, Njemačka, 07.07.2018. - 11.07.2018
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
Alzheimer's disease ; galactose ; metabolism ; trangenic mice ; cognition
Sažetak
AIMS: Decreased glucose metabolism and energy in the brain accompanies sporadic Alzheimer’s disease (sAD). Our recent research revealed that oral galactose, an alternative source of energy, successfully prevented the development/normalized early-developed cognitive deficits in a nontransgenic sAD rat model. We aimed to explore whether oral galactose has therapeutic effects on cognitive deficits in transgenic mice model of familial AD. METHODS: 80 male transgenic Tg2576 (WT/TG) and wild-type (WT/WT) mice aged 5 and 10 months underwent 2-month drink of oral galactose solution (+GAL) or tap water. Morris Water Maze (MWM), intraperitoneal glucose tolerance test, and fluorodeoxyglucose Positron-Emission- Tomography (PET) scanning were performed before sacrifice. RESULTS: MWM showed no deficits in 7-month but significant (p=0.029) cognitive decline in 12- month aged WT/TG mice compared to their respective WT/WT controls (-75%/probe trial) associated with markedly decreased movement pattern which worsened by galactose treatment in WT/WT and WT/TG groups. PET scans demonstrated increased (+19.65%) and decreased (-17.70%) glucose uptake/metabolism in the whole brain of 7- and 12-month aged WT/TG mice, which were normalized by galactose (decreased -13.90%/7-month and increased +32.09%/12-month aged WT/TG+GAL mice) respectively. Compared to WT/WT, WT/TG group showed impaired glucose tolerance only at 12- months (glucose level increased +16 to +72%) further worsened by galactose treatment (additional +21 to +51% increment, p<0.05). Galactose treatment had no effects in 12-month aged WT/WT group but lowered glucose levels in 7-month old group (-32 to -45%). CONCLUSION: Oral galactose worsens peripheral but improves central glucose homeostasis without affecting memory in cognitively impaired transgenic AD mice. Supported by HRZZ-IP-09-2014-4639.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-4639 - TERAPIJSKI POTENCIJAL ORALNE GALAKTOZE U EKSPERIMENTALNOJ ALZHEIMEROVOJ BOLESTI (GALAD) (Melita Šalković, Petrišić) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb
Profili:
Melita Šalković-Petrišić
(autor)
Ana Babić Perhoč
(autor)
Ana Knezović
(autor)
Robert Bagarić
(autor)
Vladimir Farkaš
(autor)
Jelena Osmanović
(autor)