Naslov
Tumor-associated macrophages in invasive breast cancer

Autori
Jonjić, Nives ; Lučin, Ksenija ; Mustać, Elvira ; Sasso, Franco ; Valković, Toni ; Melato, Mauro

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the IIAR Conferences 1997, Anticancer Research 17 (1997), 6A / Delinassios, J. G ; Azoudis, S ; Iliadis, E. - Atena : International Institute of Anticancer Research, 1997, 4040-4040

Skup
International Conference on Gene Therapy in Cancer

Mjesto i datum
Atena, Grčka, 27.09.1997. - 30.09.1997

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Sažetak
Tumor-associated macrophages (TAM) have several functions related to tumor biology including growth and proliferative rate, stroma formation and dissolution, neovascularisation. Monocyte chemotactic protein-1 (MCP-1) is a chemokine which induces chemotactic migration of leukocytes, particularly monocytes. The aim of our study was to define the TAM density in 81 invasive breast carcinomas and to correlate TAM density values with lymph node status, tumor grade and size, mitotic activity index (MAI) and microvesel count. MCP-1 expression was considered in order to explore its role in regulating macrophages infiltration. Widespread macrophage infiltrates were significantly more frequent in tumors ranging from 1 to 2 cm if compared to those smaller than 1 cm of bigger than 2 cm (p=0,023). Furthermore, statistical analysis showed a positive association between macrophages density and MAI (p=0,042). No correlation between macrophages density and lymph node involvement, tumor grade, microvessels count was found. Furthermore, TAM levels and MCP-1 expression were not correlated. According to our results on invasive breast cancer, MCP-1, a tumor derived chemotactic factor, is not involved in regulation of monocyte extravasation although these cells, being correlated to MAI, play a role in tumor growth.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA