Naslov
Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets

Autori
Sabol, Maja ; Trnski, Diana ; Musani, Vesna ; Ozretić, Petar ; Levanat, Sonja

Izvornik
International journal of molecular sciences (1422-0067) 19 (2018), 9; 2562, 37

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
HH-GLI signaling pathway ; GLI transcription factors ; signal transduction ; malformations ; cancer ; therapy

Sažetak
GLI transcription factors have important roles in intracellular signaling cascade, acting as the main mediators of the HH-GLI signaling pathway. This is one of the major developmental pathways, regulated both canonically and non-canonically. Deregulation of the pathway during development leads to a number of developmental malformations, depending on the deregulated pathway component. The HH-GLI pathway is mostly inactive in the adult organism but retains its function in stem cells. Aberrant activation in adult cells leads to carcinogenesis through overactivation of several tightly regulated cellular processes such as proliferation, angiogenesis, EMT. Targeting GLI transcription factors has recently become a major focus of potential therapeutic protocols.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA