Pregled bibliografske jedinice broj: 949424
Immunoglobulin G glycosylation in aging and diseases
Immunoglobulin G glycosylation in aging and diseases // Cellular Immunology, 1 (2018), 1; YCIMM3836, 42 doi:10.1016/j.cellimm.2018.07.009 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 949424 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Immunoglobulin G glycosylation in aging and diseases
Autori
Gudelj, Ivan ; Lauc, Gordan ; Pezer, Marija
Izvornik
Cellular Immunology (0008-8749) 1
(2018), 1;
YCIMM3836, 42
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
IgG glycome, aging, disease, biological age, differential glycosylation, biomarker
Sažetak
The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows a significant degree of variation within populations. IgG glycome composition is influenced both by genes and by environment, making it an excellent biomarker of a person's general health state, i.e. biological age. IgG glycosylation appears to be highly regulated, both during homeostasis and in cases of its disturbance. Changes in IgG glycosylation patterns have been observed in aging and in various diseases. Differential IgG glycosylation is known to modulate IgG effector functions and is involved in disease development and progression, representing both a predisposition and a functional mechanism involved in disease pathology. This makes IgG glycosylation analysis a promising add-on to improve existing disease biomarkers.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
