Naslov
Biochemical studies of oximes synthesized in Croatia over the past decades

Autori
Simeon-Rudolf, Vera ; Reiner, Elsa

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of the Chemical and Biological Medical Treatment Symposium-CBMTS-Industry II and The First World Congress on Chemical and Biological Terrorism, Dubrovnik, 2001 / Price, Richard - Aberdeen (MD) : Applied Science and Analyst ASA, 2002, 124-128

Skup
The Chemical and Biological Medical Treatment Symposium&#8211 ; ; CBMTS&#8211 ; ; Industry II and The First World Congress on Chemical and Biological Terrorism

Mjesto i datum
Dubrovnik, Hrvatska, 21.04.2001. - 27.04.2001

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acetylcholinesterase; organophosphates; oxime reactivation; oximes synthesis

Sažetak
This paper gives a short review of biochemical research of oximes sythesized in Croatia over the past two decades. The synthesized compounds contained one or two oxime groups at various positions on pyridinium, imidazolium, or quinuclidinium rings. Aromatic rings of some compounds were substituted with aliphatic or aromatic radicals. Biochemical studies of the oximes focused on the mechanism of reversible binding of oximes to cholinesterases, reactivation of phosphorylated cholinesterases, protection of the enzyme against inhibition by the organophosphates (Soman, Sarin, Tabun, VX or DDVP), and interaction of oximes with thiocholine substrates.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA