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Pregled bibliografske jedinice broj: 941162

Impact of cyclodextrin encapsulation on biological activity of olive pomace extracts


Radić, Kristina; Jurmanović, Sanja; Dominko, Lucija; Vitali Čepo, Dubravka; Grdić Rajković, Marija
Impact of cyclodextrin encapsulation on biological activity of olive pomace extracts // Knjiga sažetaka - 7. Simpozij studenata farmacije i medicinske biokemije
Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2018. str. 23-23 (predavanje, domaća recenzija, sažetak, ostalo)


CROSBI ID: 941162 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Impact of cyclodextrin encapsulation on biological activity of olive pomace extracts

Autori
Radić, Kristina ; Jurmanović, Sanja ; Dominko, Lucija ; Vitali Čepo, Dubravka ; Grdić Rajković, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Knjiga sažetaka - 7. Simpozij studenata farmacije i medicinske biokemije / - Zagreb : Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2018, 23-23

ISBN
978-953-6256-98-3

Skup
7. Simpozij studenata farmacije i medicinske biokemije

Mjesto i datum
Zagreb, Hrvatska, 01.06.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
olive pomace, antioxidant activity, encapsulation, cyclodextrin, in vitro bioavailability

Sažetak
Olive pomace extracts have the polyphenolic composition similar to olive oil, and therefore have a high potential as a raw material for the development of nutraceuticals and food supplements. In the framework of this research, olive pomace extracts have been prepared by previously optimized microwave extraction with or without the addition of cyclodextrins (native sample). Cyclodextrins (hydroxypropyl-β (HPβCD) and randomly methylated (RAMEB)) were used for improving the polyphenols yield, organoleptic characteristics, and stability of obtained extracts. The aim of this study was to investigate the effect of cyclodextrin encapsulation on the biological activity of olive pomace. For this purpose, samples were subjected to simulation of in vitro gastrointestinal digestion with dialysis membranes. Antioxidant activity of soluble and dialyzable fractions of extracts were investigated using the Folin-Ciocalteu and TEAC methods as well as on the model of scission of plasmid DNA. The results indicate that the presence of cyclodextrins in the extracts has a positive effect on antioxidative potential of soluble fractions of the sample, but reduces the biological activity of dialyzable fractions, probably due to the aggregation of the encapsulated complex. DNA scission model shows that cyclodextrins significantly reinforce the protective effects of native extract ; EC50 values were reduced from 81 mg/L at the native sample to 51 mg/L at the sample with the HPβCD, i.e. on 63 mg/L at the sample with RAMEB. Based on the conducted research we conclude that olive pomace polyphenol encapsulation with cyclodextrins have significant positive effects on some aspects of the biological activity of obtained extracts.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekti:
HRZZ-UIP-2014-09-9143 - Održivi razvoj inovacije u hrani - valorizacija otpada masline (NutriOliWa) (Vitali Čepo, Dubravka, HRZZ - 2014-09) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb


Citiraj ovu publikaciju:

Radić, Kristina; Jurmanović, Sanja; Dominko, Lucija; Vitali Čepo, Dubravka; Grdić Rajković, Marija
Impact of cyclodextrin encapsulation on biological activity of olive pomace extracts // Knjiga sažetaka - 7. Simpozij studenata farmacije i medicinske biokemije
Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2018. str. 23-23 (predavanje, domaća recenzija, sažetak, ostalo)
Radić, K., Jurmanović, S., Dominko, L., Vitali Čepo, D. & Grdić Rajković, M. (2018) Impact of cyclodextrin encapsulation on biological activity of olive pomace extracts. U: Knjiga sažetaka - 7. Simpozij studenata farmacije i medicinske biokemije.
@article{article, author = {Radi\'{c}, Kristina and Jurmanovi\'{c}, Sanja and Dominko, Lucija and Vitali \v{C}epo, Dubravka and Grdi\'{c} Rajkovi\'{c}, Marija}, year = {2018}, pages = {23-23}, keywords = {olive pomace, antioxidant activity, encapsulation, cyclodextrin, in vitro bioavailability}, isbn = {978-953-6256-98-3}, title = {Impact of cyclodextrin encapsulation on biological activity of olive pomace extracts}, keyword = {olive pomace, antioxidant activity, encapsulation, cyclodextrin, in vitro bioavailability}, publisher = {Farmaceutsko-biokemijski fakultet Sveu\v{c}ili\v{s}ta u Zagrebu}, publisherplace = {Zagreb, Hrvatska} }
@article{article, author = {Radi\'{c}, Kristina and Jurmanovi\'{c}, Sanja and Dominko, Lucija and Vitali \v{C}epo, Dubravka and Grdi\'{c} Rajkovi\'{c}, Marija}, year = {2018}, pages = {23-23}, keywords = {olive pomace, antioxidant activity, encapsulation, cyclodextrin, in vitro bioavailability}, isbn = {978-953-6256-98-3}, title = {Impact of cyclodextrin encapsulation on biological activity of olive pomace extracts}, keyword = {olive pomace, antioxidant activity, encapsulation, cyclodextrin, in vitro bioavailability}, publisher = {Farmaceutsko-biokemijski fakultet Sveu\v{c}ili\v{s}ta u Zagrebu}, publisherplace = {Zagreb, Hrvatska} }




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