Pregled bibliografske jedinice broj: 940667
Glutamic acid‐related hydrazine reagent for the derivatization of carbonyl compounds
Glutamic acid‐related hydrazine reagent for the derivatization of carbonyl compounds // Journal of mass spectrometry, 53 (2018), 8; 649-654 doi:10.1002/jms.4201 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 940667 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Glutamic acid‐related hydrazine reagent for the derivatization of carbonyl compounds
Autori
Brkljačić, Lidija ; Jerić, Ivanka
Izvornik
Journal of mass spectrometry (1076-5174) 53
(2018), 8;
649-654
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
carbonyl compounds ; derivatization ; MS/MS analysis ; hydrazine reagent ; hydrazones
(carbonyl compounds ; derivatization ; MS/MS analysis ; hydrazine reagent, hydrazones)
Sažetak
Chemical derivatization of carbonyl compounds is a prerequisite for their determination in environmental and biological samples by LC-MS/MS analysis. The main requirements in regard to the good derivatization reagent are fast, selective and quantitative reaction with carbonyl compounds, and efficient fragmentation upon collision-induced dissociation (CID). We have prepared glutamic acid-related hydrazine reagent, and optimized derivatization procedure with benzaldehyde as a model carbonyl compound. The CID spectrum of the obtained hydrazone gave rich fragmentation pattern with numerous abundant fragment ions. Structure-specific fragment ions were selected for the development of sensitive multiple reaction monitoring (MRM) method.
Izvorni jezik
Hrvatski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-3102 - Višekomponentne reakcije u sintezi peptidnih mimetika (MIMICRy) (Jerić, Ivanka, HRZZ - 2014-09) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Poveznice na cjeloviti tekst rada:
doi analyticalsciencejournals.onlinelibrary.wiley.com onlinelibrary.wiley.comCitiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
