Naslov
Konformacijska i kirooptička svojstva bis- ferocenskih peptida
(Conformational and chirooptical properties of bis- ferrocene peptides)

Autori
Nuskol, Marko ; Kodrin, Ivan ; Studen, Bosiljka ; Čakić Semenčić, Mojca

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XII. Susret mladih kemijskih inženjera : knjiga sažetaka / Vrsaljko, Domagoj ; Dejanović, Igor ; Žižek, Krunoslav - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2018, 176-176

ISBN
978-953-6894-62-8

Skup
XII. susret mladih kemijskih inženjera (SMLKI 2018)

Mjesto i datum
Zagreb, Hrvatska, 22.02.2018. - 23.02.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
ferocen, konformacijska analiza, peptidi, CD-spektroskopija
(ferrocene, conformational analysis, peptides, CD-spectroscopy)

Sažetak
We have recently demonstrated that simple conjugates of aminoferocene and peptides I (Boc- Pro-Ala-NH-Fc) are able to form ordered secondary structural elements, while homo- or heterocirality of the amino acid sequence determines the formation of beta- or gamma-turns. Furthermore, the perturbation of inherently achiral ferrocene chromophore, caused by chiral dipeptide sequence, causes the modification of its chiroptical properties and gives rise to CD-activity in the spectral region of the absorbing chromophore. As a continuation of this study, we have synthesized dinuclear derivatives II (Fc-CO-Pro-Ala-NH-Fc) to get a deeper insight into structural preferences and fine-tuning properties of ferrocene-based peptidomimetics. Thorough spectroscopic analysis in combination with DFT calculations revealed the presence of beta-turns in the most stable conformations of II. Moreover, different shapes and intensities of bands around the UV/Vis absorption maximum of the ferrocene chromophore in circular dichroism spectra of I and II open up an opportunity to use ferrocene as a receptor for sensing secondary structures of small peptides.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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