Naslov
Effects of different n6/n3 ratios and supplementation with DHA and EPA on the testicular histology and lipogenesis in streptozotocin treated rats

Autori
Starčević, Kristina ; Maurić, Maja ; Galan, Asier ; Gudan Kurilj, Andrea ; Mašek, Tomislav

Izvornik
Andrologia (Berlin) (0303-4569) 50 (2018), 8; E13067, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
lipid peroxidation, n6/n3 ratio, streptozotocin, testicular lipogenesis

Sažetak
The aim of this study was to investigate the possible influence of different dietary n6/n3 ratios and DHA/EPA addition on the testis histology, antioxidative status and lipogenesis of streptozotocin treated rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin (55 mg/kg). The rats were divided into 5 groups: CON (n6/n3 ratio, 7), CON-DM1 (STZ ; n6/n3 ratio, 7), N3-DM1 (STZ ; n6/n3 ratio, 1), N6-DM1 (STZ ; n6/n3 ratio, 60) and DHA-DM1 (STZ ; n6/n3 ratio, 1 ; added DHA/EPA). Antioxidative status was improved in the DHA-DM1 group. Seminiferous tubule diameter, testicular pathohistological scoring and total lipid content were improved in the N6-DM1 group compared to the other streptozotocin treated groups. Streptozotocin treatment induced changes in testis fatty acid profile depending on n6/n3 ratio. The fatty acid profile of N6-DM1 group was characterized by similar or increased values for n6 fatty acids compared to the CON group, while the DHA- DM1 group had the lowest content of n6 fatty acids. The content of n3 fatty acids was increased in the N3-DM1 and DHA-DM1 groups. These results suggest that a n6/n3 ratio could significantly influence testicular antioxidative status, histology and lipogenesis, and that these effects vary depending on the supplemented fatty acid.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA