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Pregled bibliografske jedinice broj: 938525

Synthesis and in vitro evaluation of antiviral and cytostatic properties of novel 8-triazolyl acyclovir derivatives


Saftić, Dijana; Žinić, Biserka; Glavaš- Obrovac, Ljubica; Studzińska, Mirosława; Paradowska, Edyta; Leśnikowski, Zbigniew J.
Synthesis and in vitro evaluation of antiviral and cytostatic properties of novel 8-triazolyl acyclovir derivatives // Nucleosides, nucleotides & nucleic acids, 37 (2018), 7; 397-414 doi:10.1080/15257770.2018.1485932 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 938525 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis and in vitro evaluation of antiviral and cytostatic properties of novel 8-triazolyl acyclovir derivatives

Autori
Saftić, Dijana ; Žinić, Biserka ; Glavaš- Obrovac, Ljubica ; Studzińska, Mirosława ; Paradowska, Edyta ; Leśnikowski, Zbigniew J.

Izvornik
Nucleosides, nucleotides & nucleic acids (1525-7770) 37 (2018), 7; 397-414

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
8-triazolyl acyclovir ; 1, 4-disubstituted 1, 2, 3-triazole ; cytotoxic activity ; antiviral activity

Sažetak
As a part of the research aimed on identification of new nucleobase derivatives with improved biological properties, a series of novel 8-substituted acyclovir derivatives were synthesized. The 8-azidoguanosine 4 and novel 8-azidoacyclovir 9 were synthesized from commercially available guanosine 1 and acyclovir 6 which were transformed into 8- bromopurine derivatives 2 and 7 and hydrazine derivatives 3 and 8, respectively. 8- Triazolylguanosine 5 and 8- triazolylacyclovir analogs 1012 were successfully synthesized via the Cu(I) catalyzed 1, 3-dipolar cycloaddition reaction of azides 4 and 9 with propargyl alcohol, 4-pentyn-1-ol and 5-hexyn-1-ol. The novel 1, 4-disubstituted 1, 2, 3-triazolyl compounds 5, 1012 were evaluated for antiviral activity against selected DNA and RNA viruses and cytostatic activity against normal Madine Darby canine kidney (MDCK I) cells, and seven tumor cell lines (HeLa, CaCo-2, NCI-H358, Jurkat, K562, Raji and HuT78). While tested compounds exerted no antiviral activity at nontoxic concentrations, the 8-triazolyl acyclovir derivative 10, with the shortest alkyl substituent at the C-4 of triazole ring, was found to be the most active against the CaCo-2 cell line.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
098-0982914-2935 - Sinteza novih biološki aktivnih derivata nukleobaza i nukleotida (Žinić, Biserka, MZOS ) ( CroRIS)
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA/RNA sekundarne strukture molekularnim kemijskim senzorima (DNA/RNA-MolSense) (Piantanida, Ivo, HRZZ - 2013-11) ( CroRIS)
219-0982914-2176 - Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjeka (Glavaš Obrovac, Ljubica, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

doi www.tandfonline.com doi.org

Citiraj ovu publikaciju:

Saftić, Dijana; Žinić, Biserka; Glavaš- Obrovac, Ljubica; Studzińska, Mirosława; Paradowska, Edyta; Leśnikowski, Zbigniew J.
Synthesis and in vitro evaluation of antiviral and cytostatic properties of novel 8-triazolyl acyclovir derivatives // Nucleosides, nucleotides & nucleic acids, 37 (2018), 7; 397-414 doi:10.1080/15257770.2018.1485932 (međunarodna recenzija, članak, znanstveni)
Saftić, D., Žinić, B., Glavaš- Obrovac, L., Studzińska, M., Paradowska, E. & Leśnikowski, Z. (2018) Synthesis and in vitro evaluation of antiviral and cytostatic properties of novel 8-triazolyl acyclovir derivatives. Nucleosides, nucleotides & nucleic acids, 37 (7), 397-414 doi:10.1080/15257770.2018.1485932.
@article{article, author = {Safti\'{c}, Dijana and \v{Z}ini\'{c}, Biserka and Glava\v{s}- Obrovac, Ljubica and Studzi\'{n}ska, Miros\lawa and Paradowska, Edyta and Le\'{s}nikowski, Zbigniew J.}, year = {2018}, pages = {397-414}, DOI = {10.1080/15257770.2018.1485932}, keywords = {8-triazolyl acyclovir, 1, 4-disubstituted 1, 2, 3-triazole, cytotoxic activity, antiviral activity}, journal = {Nucleosides, nucleotides and nucleic acids}, doi = {10.1080/15257770.2018.1485932}, volume = {37}, number = {7}, issn = {1525-7770}, title = {Synthesis and in vitro evaluation of antiviral and cytostatic properties of novel 8-triazolyl acyclovir derivatives}, keyword = {8-triazolyl acyclovir, 1, 4-disubstituted 1, 2, 3-triazole, cytotoxic activity, antiviral activity} }
@article{article, author = {Safti\'{c}, Dijana and \v{Z}ini\'{c}, Biserka and Glava\v{s}- Obrovac, Ljubica and Studzi\'{n}ska, Miros\lawa and Paradowska, Edyta and Le\'{s}nikowski, Zbigniew J.}, year = {2018}, pages = {397-414}, DOI = {10.1080/15257770.2018.1485932}, keywords = {8-triazolyl acyclovir, 1, 4-disubstituted 1, 2, 3-triazole, cytotoxic activity, antiviral activity}, journal = {Nucleosides, nucleotides and nucleic acids}, doi = {10.1080/15257770.2018.1485932}, volume = {37}, number = {7}, issn = {1525-7770}, title = {Synthesis and in vitro evaluation of antiviral and cytostatic properties of novel 8-triazolyl acyclovir derivatives}, keyword = {8-triazolyl acyclovir, 1, 4-disubstituted 1, 2, 3-triazole, cytotoxic activity, antiviral activity} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Arts & Humanities Citation Index (A&HCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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