Pregled bibliografske jedinice broj: 938500
Cell penetrating, mitochondria targeting multiply charged DABCO-cyanine dyes
Cell penetrating, mitochondria targeting multiply charged DABCO-cyanine dyes // Dyes and pigments, 158 (2018), 517-525 doi:10.1016/j.dyepig.2018.05.035 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 938500 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Cell penetrating, mitochondria targeting multiply charged DABCO-cyanine dyes
Autori
Kurutos, Atanas ; Orehovec, Iva ; Saftić, Dijana ; Horvat, Lucija ; Crnolatac, Ivo ; Piantanida, Ivo ; Deligeorgiev, Todor
Izvornik
Dyes and pigments (0143-7208) 158
(2018);
517-525
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
cyanine ; DABCO ; mitochondria ; fluorescence ; confocal microscopy
Sažetak
We have prepared new series of lipophilic cyanine dyes equipped with several cationic quaternary ammonium moieties. This was achieved by introducing DABCO within the structures. Furthermore, to investigate the influence of the additional cationic charges to the mitochondrial uptake, DABCO was quaternized with methyl group or alkyl piperidine cation. Spectroscopic and isothermal titration calorimetry studies as well as MTT assay and subcellular localization using confocal laser scanning microscopy revealed the presented dyes combine very low cytotoxicity with efficient cellular uptake and remarkable fluorescent marking of mitochondria.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Projekti:
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA/RNA sekundarne strukture molekularnim kemijskim senzorima (DNA/RNA-MolSense) (Piantanida, Ivo, HRZZ - 2013-11) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Ivo Crnolatac
(autor)
Ivo Piantanida
(autor)
Iva Orehovec
(autor)
Dijana Pavlović Saftić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus