Naslov
Great Efficiency of Nucleosides as Organizing Tools

Autori
Merkaš, Sonja ; Bouatra, Souhaila ; Rein, Régis ; Piantanida, Ivo ; Žinić, Mladen ; Solladié, Nathalie

Izvornik
Croatica chemica acta (0011-1643) 90 (2017), 4; 595-602

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
porphyrins ; tweezers ; nucleosides ; molecular recognition

Sažetak
Bis-porphyrins with flexible linkers such as uridine or 2’-deoxyuridin pre-organize in a face-to-face conformation and form stable sandwich complexes with bidentate base such as DABCO. The gain in stability can be even greater when a dinucleotide linker is used. Such pre-organization increases the association constant by one to two orders of magnitude when compared to the one of DABCO with a reference porphyrin. Comparison with rigid tweezers shows a better efficiency of nucleosidic dimers. The choice of rigid spacers is not the only way to pre-organize bis-porphyrins, and well-chosen nucleosidic linkers offer an interesting option for the synthesis of such devices.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA