Pregled bibliografske jedinice broj: 936788
Associations between apolipoprotein E genotypes and Hg concentrations in cord blood
Associations between apolipoprotein E genotypes and Hg concentrations in cord blood // Programme and abstract book / Manno, Maurizio (ur.).
Napulj: the Scientific Committee of Occupational Toxicology (SCOT) of the International Commission on Occupational Health (ICOH), in collaboration with the University of Naples Federico II, 2017. str. 83-83 (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 936788 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Associations between apolipoprotein E genotypes and Hg concentrations in cord blood
Autori
Trdin, Anja ; Falnoga, Ingrid ; Snoj Tratnik, Janja ; Stajnko, Anja ; Mazej, Darja ; Marc, Janja ; Krsnik, Mladen ; Osredkar, Joško ; Prpić, Igor ; Petrović, Oleg ; Špirić, Zdravko ; Horvat, Milena
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Programme and abstract book
/ Manno, Maurizio - Napulj : The Scientific Committee of Occupational Toxicology (SCOT) of the International Commission on Occupational Health (ICOH), in collaboration with the University of Naples Federico II, 2017, 83-83
Skup
10th International Symposium on Biological Monitoring in Occupational and Environmental Health (ISBM-10)
Mjesto i datum
Napulj, Italija, 01.10.2017. - 04.10.2017
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
apolipoprotein E, genotypes, Hg concentrations in cord blood
Sažetak
The aim of present study was to estimate the potential relations between APOE polymorphisms and concentrations of total, methyl and inorganic Hg (tHg, MeHg, iHg) in cord blood (CB) of newborns whose mothers were exposed to Hg through fish consumption. We were focused on impact of APOE polymorphism of mothers and/or their newborns, since it is not clear whose genotypes could have greater impact on placental toxicokinetics. Mothers (n=398) and newborns (n=573) from central Slovenia and coastal Croatia, participants of EU projects PHIME and CROME-LIFE+, were included in the study. We used existed data set of personal (and lifestyle) characteristics, tHg blood concentrations and archived DNA extracts from maternal leukocytes and cord tissues. CB MeHg was additionally measured by CVAFS (Tekran 2700), iHg estimated by subtraction of MeHg from tHg and DNA genotyped for APOE (rs429358 and rs7412) by TaqMan® SNP assay (Applied Biosystems). Statistics: Wilcoxon rank-sum test, multiple linear regression (STATA).
Izvorni jezik
Engleski
Znanstvena područja
Interdisciplinarne tehničke znanosti, Biotehnologija, Interdisciplinarne biotehničke znanosti
POVEZANOST RADA
Projekti:
273-0222882-2698 - Bioindikacija onečišćenja zraka u terestričkim ekosustavima
Ustanove:
Medicinski fakultet, Rijeka,
OIKON d.o.o.