Naslov
Positive association of apolipoprotein E allel ε4 with plasma selenium in Croatian pregnant females

Autori
Snoj Tratnik, Janja ; Stajnko, Anja ; Marc, Janja ; Mazej, Darja ; Prpić, Igor ; Špirić, Zdravko ; Horvat, Milena ; Falnoga, Ingrid

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The 11th International Symposium on Selenium in Biology and Medicine and The 5th International Conference on Selenium in theEnvironment and Human Health - Programme and abstract book / Arnér, Elias - Stockholm : Karolinska Institutet, Sweden, 2017, 271-271

Skup
The 11th International Symposium on Selenium in Biology and Medicine and The 5th International Conference on Selenium in theEnvironment and Human Health

Mjesto i datum
Stockholm, Švedska, 13.08.2017. - 17.08.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
selenium status, apolipoprotein E, APOE polymorphism, metal(loid)s

Sažetak
Introduction: Relation between apolipoprotein E gene (APOE) polymorphisms (allel ε4 carriers versus non carriers) and metal(loid)s (Hg, As, Pb, Cd, Se) in mothers and their newborns exposed to seafood metal(loid)s was investigated. Apo E is a lipid binding glycoprotein involved in lipid and neuronal metabolism, having antioxidative, metal-binding and immunomodulatory/anti-inflammatory effects. Its three isoforms are encoded by alleles ε2, ε3 and ε4, respectively. Allel ε4 is believed to be beneficial early in life and detrimental in age related diseases3. ε4 carriers could be more susceptible to oxidative stress and metal toxicity. Discussion: Superior selenium status found in healthy pregnant females carriyng allel ε4 could be linked to the ‘APOE ε4 beneficial effects early in life’

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Biotehnologija, Interdisciplinarne biotehničke znanosti

POVEZANOST RADA