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Pregled bibliografske jedinice broj: 936284

Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats

Rašić, Dubravka; Mladinić, Marin; Želježić, Davor; Pizent, Alica; Stefanović, Srđan; Milićević, Dragan; Konjevoda, Paško; Peraica, Maja
Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats // Toxicon, 146 (2018), 99-105 doi:10.1016/j.toxicon.2018.03.002 (međunarodna recenzija, članak, znanstveni)

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Naslov
Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats

Autori
Rašić, Dubravka ; Mladinić, Marin ; Želježić, Davor ; Pizent, Alica ; Stefanović, Srđan ; Milićević, Dragan ; Konjevoda, Paško ; Peraica, Maja

Izvornik
Toxicon (0041-0101) 146 (2018); 99-105

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
citrinin ; DNA damage ; ochratoxin A ; oxidative stress ; resveratrol

Sažetak
A multimycotoxin analysis approach in grains results in frequent simultaneous findings of nephrotoxic mycotoxins ochratoxin A (OTA) and citrinin (CTN). The mechanism of CTN and OTA toxicities in biological systems is not fully understood but it is known that oxidative stress is involved. In this study, oxidative damage of DNA, lipids, and the concentration of glutathione (GSH), as well as possible antioxidative effects of resveratrol (RSV) were studied in vivo. Male adult Wistar rats were treated orally with OTA (0.125 and 0.250 mg kg- 1 b.w.), RSV (20 mg kg-1 b.w.) for 21 days, CTN (20 mg kg-1 b.w.) for two days or with their combinations. The hOGG1 modified comet assay revealed kidneys and liver oxidative DNA damage in OTA + CTN treated animals, which was not reversed by RSV. CTN did not reduce glutathione (GSH) or increase malondialdehyde (MDA) concentration in any tissue, while OTA reduced kidneys GSH and increased kidneys and liver MDA. RSV increased GSH concentrations in all tissues and decreased MDA concentration in the liver only. Oxidative stress is involved in the toxicity of OTA and CTN but it seems that it differs significantly in organs. Most of the effects on GSH and MDA in combined toxicity may be attributed to the toxic effects of OTA. RSV was effective in restoring the depleted GSH in all tissues but had no effect on the MDA concentration and DNA damage.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Paško Konjevoda (autor)

Avatar Url Dubravka Rašić (autor)

Avatar Url Alica Pizent (autor)

Avatar Url Marin Mladinić (autor)

Avatar Url Maja Peraica (autor)

Avatar Url Davor Želježić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Rašić, Dubravka; Mladinić, Marin; Želježić, Davor; Pizent, Alica; Stefanović, Srđan; Milićević, Dragan; Konjevoda, Paško; Peraica, Maja
Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats // Toxicon, 146 (2018), 99-105 doi:10.1016/j.toxicon.2018.03.002 (međunarodna recenzija, članak, znanstveni)
Rašić, D., Mladinić, M., Želježić, D., Pizent, A., Stefanović, S., Milićević, D., Konjevoda, P. & Peraica, M. (2018) Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats. Toxicon, 146, 99-105 doi:10.1016/j.toxicon.2018.03.002.
@article{article, author = {Ra\v{s}i\'{c}, Dubravka and Mladini\'{c}, Marin and \v{Z}elje\v{z}i\'{c}, Davor and Pizent, Alica and Stefanovi\'{c}, Sr\djan and Mili\'{c}evi\'{c}, Dragan and Konjevoda, Pa\v{s}ko and Peraica, Maja}, year = {2018}, pages = {99-105}, DOI = {10.1016/j.toxicon.2018.03.002}, keywords = {citrinin, DNA damage, ochratoxin A, oxidative stress, resveratrol}, journal = {Toxicon}, doi = {10.1016/j.toxicon.2018.03.002}, volume = {146}, issn = {0041-0101}, title = {Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats}, keyword = {citrinin, DNA damage, ochratoxin A, oxidative stress, resveratrol} }
@article{article, author = {Ra\v{s}i\'{c}, Dubravka and Mladini\'{c}, Marin and \v{Z}elje\v{z}i\'{c}, Davor and Pizent, Alica and Stefanovi\'{c}, Sr\djan and Mili\'{c}evi\'{c}, Dragan and Konjevoda, Pa\v{s}ko and Peraica, Maja}, year = {2018}, pages = {99-105}, DOI = {10.1016/j.toxicon.2018.03.002}, keywords = {citrinin, DNA damage, ochratoxin A, oxidative stress, resveratrol}, journal = {Toxicon}, doi = {10.1016/j.toxicon.2018.03.002}, volume = {146}, issn = {0041-0101}, title = {Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats}, keyword = {citrinin, DNA damage, ochratoxin A, oxidative stress, resveratrol} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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