Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 935653

Intestinal damage, neurotoxicity and biochemical responses caused by tris (2-chloroethyl) phosphate and tricresyl phosphate on earthworm.

Yang, Yang; Xiao, Yao; Chang, Yeqian; Cui, Yibin; Klobučar, Goran; Li, Mei
Intestinal damage, neurotoxicity and biochemical responses caused by tris (2-chloroethyl) phosphate and tricresyl phosphate on earthworm. // Ecotoxicology and Environmental Safety, 158 (2018), -; 78-86 doi:.org/10.1016/j.ecoenv.2018.04.012 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 935653 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Intestinal damage, neurotoxicity and biochemical responses caused by tris (2-chloroethyl) phosphate and tricresyl phosphate on earthworm.

Autori
Yang, Yang ; Xiao, Yao ; Chang, Yeqian ; Cui, Yibin ; Klobučar, Goran ; Li, Mei

Izvornik
Ecotoxicology and Environmental Safety (0147-6513) 158 (2018); 78-86

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA damage ; Eisenia fetida ; Histopathological examination ; Integrated biological response ; Oxidative stress

Sažetak
Organophosphate esters (OPEs) draw growing concern about characterizing the potential risk on environmental health due to its wide usage and distribution. Two typical types of organophosphate esters (OPEs): tris (2-chloroethyl) phosphate (TCEP) and tricresyl phosphate (TCP) were selected to evaluate toxicity of OPEs to the soil organism like earthworm (Eisenia fetida). Histopathological examination (H&E), oxidative stress, DNA damage and RT-qPCR was used to identify the effects and potential mechanism of their toxicity. Hameatoxylin and eosin (H&E) demonstrated that intestinal cells suffered serious damage, and the observed up-regulation of chitinase and cathepsin L in mRNA levels confirmed it. Both TCEP and TCP significantly increased the DNA damage when the concentrations exceeded 1 mg/kg (p < 0.01), and a dose-response relationship was observed. In addition, TCEP and TCP also changed the acetylcholinesterase (AChE) activity and expression of genes associated with neurotoxic effects in earthworms even under exposure to low OPEs concentration (0.1 mg/kg). Moreover, genes associated with nicotinic acetylcholine receptors (nAChR) and carrier protein further demonstrated that highest concentration of TCEP (10 mg/kg) may have an overloading impact on the cholinergic system of E. fetida. Integrated Biological Response index (IBRv2) showed that TCEP exerted stronger toxicity than TCP under the same concentrations. We deduced that the observed intestinal damage, oxidative stress and neurotoxic effect might be the primary mechanisms of TCEP and TCP toxicity. This study provides insight into the toxicological effects of OPEs on earthworm model, and may be useful for risk assessment of OPEs on soil ecosystems.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Goran Klobučar (autor)

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Yang, Yang; Xiao, Yao; Chang, Yeqian; Cui, Yibin; Klobučar, Goran; Li, Mei
Intestinal damage, neurotoxicity and biochemical responses caused by tris (2-chloroethyl) phosphate and tricresyl phosphate on earthworm. // Ecotoxicology and Environmental Safety, 158 (2018), -; 78-86 doi:.org/10.1016/j.ecoenv.2018.04.012 (međunarodna recenzija, članak, znanstveni)
Yang, Y., Xiao, Y., Chang, Y., Cui, Y., Klobučar, G. & Li, M. (2018) Intestinal damage, neurotoxicity and biochemical responses caused by tris (2-chloroethyl) phosphate and tricresyl phosphate on earthworm.. Ecotoxicology and Environmental Safety, 158 (-), 78-86 doi:.org/10.1016/j.ecoenv.2018.04.012.
@article{article, author = {Yang, Yang and Xiao, Yao and Chang, Yeqian and Cui, Yibin and Klobu\v{c}ar, Goran and Li, Mei}, year = {2018}, pages = {78-86}, DOI = {doi.org/10.1016/j.ecoenv.2018.04.012}, keywords = {DNA damage, Eisenia fetida, Histopathological examination, Integrated biological response, Oxidative stress}, journal = {Ecotoxicology and Environmental Safety}, doi = {doi.org/10.1016/j.ecoenv.2018.04.012}, volume = {158}, number = {-}, issn = {0147-6513}, title = {Intestinal damage, neurotoxicity and biochemical responses caused by tris (2-chloroethyl) phosphate and tricresyl phosphate on earthworm.}, keyword = {DNA damage, Eisenia fetida, Histopathological examination, Integrated biological response, Oxidative stress} }
@article{article, author = {Yang, Yang and Xiao, Yao and Chang, Yeqian and Cui, Yibin and Klobu\v{c}ar, Goran and Li, Mei}, year = {2018}, pages = {78-86}, DOI = {doi.org/10.1016/j.ecoenv.2018.04.012}, keywords = {DNA damage, Eisenia fetida, Histopathological examination, Integrated biological response, Oxidative stress}, journal = {Ecotoxicology and Environmental Safety}, doi = {doi.org/10.1016/j.ecoenv.2018.04.012}, volume = {158}, number = {-}, issn = {0147-6513}, title = {Intestinal damage, neurotoxicity and biochemical responses caused by tris (2-chloroethyl) phosphate and tricresyl phosphate on earthworm.}, keyword = {DNA damage, Eisenia fetida, Histopathological examination, Integrated biological response, Oxidative stress} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
    • Emerging Sources Citation Index (ESCI)
  • Scopus
  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.