Naslov
Ferrocene bioconjugates

Autori
Čakić Semenčić, Mojca ; Barišić, Lidija

Izvornik
Croatica chemica acta (0011-1643) 90 (2018); 537-569

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Ferrocene ; Resveratrol ; Mannose ; Oxalamide ; Peptide ; Cytoxic activity ; Hemagglutination, Gelation ; Conformational analysis ; Peptidomimetics

Sažetak
In this review we present our recent contribution to the field of bioorganometallic chemistry of ferrocene. Ferrocene conjugates with biomolecules have been synthesized and characterized using IR and NMR (1H, 13C, COSY, NOESY, HMBC) spectroscopy, ESI-MS and HRMS. The bioconjugates of ferrocene with resveratrol (2) and mannose (10, 11, 14 and 15) were biologically evaluated for their potential inhibitory effect on HepG2 cancer cells (2) and E. coli adherence to the bladder epithelium (10, 11, 14 and 15). The oxalamide-bridged ferrocene 17 was subjected to conformational analysis in solution and in the solid state, and tested for its gelation and cytotoxic activity. The mono- (30-32, 36-38, 42-45) and disubstituted ferrocene conjugates with natural amino acids (21-28, 33-35, 39-41, 48, 49, 62-65, 69-72) were subjected to the detailed conformational and DFT analyses in order to determine the turn-inducing potential of ferrocene scaffolds in the corresponding peptidomimetics.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA