Naslov
Characterization and microbiological evaluation of chitosan-alginate microspheres for cefixime vaginal administration

Autori
Maestrelli, Francesca ; Jug, Mario ; Cirri, Marzia ; Kosalec, Ivan ; Mura, Paola

Izvornik
Carbohydrate polymers (0144-8617) 192 (2018); 176-183

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chitosan ; alginate ; microspheres ; vaginal delivery ; mucoadhesion ; cefixime

Sažetak
Chitosan-alginate microspheres (MS) were developed for cefixime vaginal administration, to overcome problems associated with its oral administration. The effect of increasing drug-loading amount, by keeping the chitosan-alginate content constant, was investigated. Mucoadhesion studies indicated that all formulations assured in situ permanence longer than 2 h. Entrapment efficiency increased with drug loading concentration in the starting solution, reaching a plateau at 30 mg/mL indicative of the achievement of an optimal drug-to-polymer ratio. MS swelling properties increased with the entrapped drug amount, and, interestingly, water-uptake reached its maximum value at the same drug loading concentration of 30 mg/mL. The relationship found between MS water-uptake and drug release rate confirmed MS prepared with 30 mg/mL cefixime as the best formulation. Microbiological studies showed a relation between cefixime release rate from MS and Escherichia coli viability reduction, definitely indicating the selected MS formulation as the best for an effective local treatment of urogenital infections.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA