Naslov
Dapsone-induced agranulocytosis-possible involvement of low-activity N -acetyltransferase 2

Autori
Potočnjak, Ines ; Likić, Robert ; Šimić, Iveta ; Juričić Nahal, Danica ; Čegec, Ivana ; Ganoci, Lana ; Božina, Nada

Izvornik
Fundamental & Clinical Pharmacology (0767-3981) 31 (2017), 5; 580-586

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adverse drug reaction, agranulocytosis, pharmacogenetics, NAT2

Sažetak
Dapsone‐induced agranulocytosis is a rare but potentially fatal adverse drug reaction (ADR). A 45‐year‐old male Caucasian patient developed agranulocytosis caused by dapsone (diamino‐ diphenyl sulfone), which he was prescribed for leukocytoclastic vasculitis. Patient's treatment consisted of termination of dapsone, antibiotic therapy, and granulocyte colony‐ stimulating factor leading to prompt improvement of symptoms and normalization of laboratory blood values. Diagnostic evaluation revealed methemoglobinemia and excluded glucose‐6‐phosphate dehydrogenase deficiency. Pharmacogenetics testing showed that he was a carrier of NAT2 *5/*6 genotype, predisposing to low activity of the N‐ acetyltransferase 2 enzyme. This was the first and only ADR to dapsone reported in Croatia. In total, there have been 73 ADR to dapsone recorded worldwide, including only four cases of agranulocytosis.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti

POVEZANOST RADA