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Pregled bibliografske jedinice broj: 932243

Monoamine Oxidase A Gene Methylation and Its Role in Posttraumatic Stress Disorder: First Evidence from the South Eastern Europe (SEE)- PTSD Study

Ziegler, Christiane; Wolf, Christiane; Schiele, Miriam A; Feric Bojic, Elma; Kucukalic, Sabina; Sabic Dzananovic, Emina; Goci Uka, Aferdita; Hoxha, Blerina; Haxhibeqiri, Valdete; Haxhibeqiri, Shpend et al.
Monoamine Oxidase A Gene Methylation and Its Role in Posttraumatic Stress Disorder: First Evidence from the South Eastern Europe (SEE)- PTSD Study // International Journal of Neuropsychopharmacology, 111 (2017), pyx111, 10 doi:10.1093/ijnp/pyx111 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 932243 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Monoamine Oxidase A Gene Methylation and Its Role in Posttraumatic Stress Disorder: First Evidence from the South Eastern Europe (SEE)- PTSD Study

Autori
Ziegler, Christiane ; Wolf, Christiane ; Schiele, Miriam A ; Feric Bojic, Elma ; Kucukalic, Sabina ; Sabic Dzananovic, Emina ; Goci Uka, Aferdita ; Hoxha, Blerina ; Haxhibeqiri, Valdete ; Haxhibeqiri, Shpend ; Kravic, Nermina ; Muminovic Umihanic, Mirnesa ; Cima Franc, Ana ; Jaksic, Nenad ; Babic, Romana ; Pavlovic, Marko ; Warrings, Bodo ; Bravo Mehmedbasic, Alma ; Rudan, Dusko ; Aukst- Margetic, Branka ; Kucukalic, Abdulah ; Marjanovic, Damir ; Babic, Dragan ; Bozina, Nada ; Jakovljevic, Miro ; Sinanovic, Osman ; Avdibegovic, Esmina ; Agani, Ferid ; Dzubur- Kulenovic, Alma ; Deckert, Jürgen ; Domschke, Katharina

Izvornik
International Journal of Neuropsychopharmacology (1461-1457) 111 (2017); Pyx111, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CAPS ; DNA methylation ; MAOA ; PTSD ; epigenetics

Sažetak
BACKGROUND: Posttraumatic Stress Disorder (PTSD) is characterized by an overactive noradrenergic system conferring core PTSD symptoms such as hyperarousal and re-experiencing. Monoamine oxidase A (MAO-A) is one of the key enzymes mediating the turnover of noradrenaline. Here, DNA methylation of the MAOA gene exonI/intronI region was investigated for the first time in regards to its role in PTSD risk and severity. METHODS: MAOA methylation was analyzed via direct sequencing of sodium bisulfite treated DNA extracted from blood cells in a total sample of N=652 (m=441) patients with current PTSD, patients with remitted PTSD and healthy probands (comparison group) recruited at five centres in Bosnia-Herzegovina, Croatia, and the Republic of Kosovo. PTSD severity was measured by means of the Clinician-Administered PTSD Scale (CAPS) and its respective subscores representing distinct symptom clusters. RESULTS: In the male, but not the female sample, patients with current PTSD displayed hypermethylation of three CpGs (CpG3=43, 656, 362 ; CpG12=43, 656, 514 ; CpG13=43, 656, 553, GRCh38.p2 Assembly) as compared to remitted PTSD patients and healthy probands. Symptom severity (CAPS scores) in male patients with current PTSD significantly correlated with MAOA methylation. This applied particularly to symptom clusters related to re- experiencing of trauma (cluster 'B') and hyperarousal (cluster 'D'). CONCLUSIONS: The present findings suggest MAOA gene hypermethylation - potentially resulting in enhanced noradrenergic signalling - as a disease status and severity marker of current PTSD in males. If replicated, MAOA hypermethylation might serve as a surrogate marker of a hyperadrenergic subtype of PTSD guiding personalized treatment decisions on the use of anti-adrenergic agents.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Nada Božina (autor)

Avatar Url Dragan Babić (autor)

Avatar Url NENAD JAKŠIĆ (autor)

Avatar Url Damir Marjanović (autor)

Avatar Url Branka Aukst Margetić (autor)

Avatar Url Miro Jakovljević (autor)

Poveznice na cjeloviti tekst rada:

doi academic.oup.com

Citiraj ovu publikaciju:

Ziegler, Christiane; Wolf, Christiane; Schiele, Miriam A; Feric Bojic, Elma; Kucukalic, Sabina; Sabic Dzananovic, Emina; Goci Uka, Aferdita; Hoxha, Blerina; Haxhibeqiri, Valdete; Haxhibeqiri, Shpend et al.
Monoamine Oxidase A Gene Methylation and Its Role in Posttraumatic Stress Disorder: First Evidence from the South Eastern Europe (SEE)- PTSD Study // International Journal of Neuropsychopharmacology, 111 (2017), pyx111, 10 doi:10.1093/ijnp/pyx111 (međunarodna recenzija, članak, znanstveni)
Ziegler, C., Wolf, C., Schiele, M., Feric Bojic, E., Kucukalic, S., Sabic Dzananovic, E., Goci Uka, A., Hoxha, B., Haxhibeqiri, V. & Haxhibeqiri, S. (2017) Monoamine Oxidase A Gene Methylation and Its Role in Posttraumatic Stress Disorder: First Evidence from the South Eastern Europe (SEE)- PTSD Study. International Journal of Neuropsychopharmacology, 111, pyx111, 10 doi:10.1093/ijnp/pyx111.
@article{article, author = {Ziegler, Christiane and Wolf, Christiane and Schiele, Miriam A and Feric Bojic, Elma and Kucukalic, Sabina and Sabic Dzananovic, Emina and Goci Uka, Aferdita and Hoxha, Blerina and Haxhibeqiri, Valdete and Haxhibeqiri, Shpend and Kravic, Nermina and Muminovic Umihanic, Mirnesa and Cima Franc, Ana and Jaksic, Nenad and Babic, Romana and Pavlovic, Marko and Warrings, Bodo and Bravo Mehmedbasic, Alma and Rudan, Dusko and Aukst- Margetic, Branka and Kucukalic, Abdulah and Marjanovic, Damir and Babic, Dragan and Bozina, Nada and Jakovljevic, Miro and Sinanovic, Osman and Avdibegovic, Esmina and Agani, Ferid and Dzubur- Kulenovic, Alma and Deckert, J\"{u}rgen and Domschke, Katharina}, year = {2017}, pages = {10}, DOI = {10.1093/ijnp/pyx111}, chapter = {pyx111}, keywords = {CAPS, DNA methylation, MAOA, PTSD, epigenetics}, journal = {International Journal of Neuropsychopharmacology}, doi = {10.1093/ijnp/pyx111}, volume = {111}, issn = {1461-1457}, title = {Monoamine Oxidase A Gene Methylation and Its Role in Posttraumatic Stress Disorder: First Evidence from the South Eastern Europe (SEE)- PTSD Study}, keyword = {CAPS, DNA methylation, MAOA, PTSD, epigenetics}, chapternumber = {pyx111} }
@article{article, author = {Ziegler, Christiane and Wolf, Christiane and Schiele, Miriam A and Feric Bojic, Elma and Kucukalic, Sabina and Sabic Dzananovic, Emina and Goci Uka, Aferdita and Hoxha, Blerina and Haxhibeqiri, Valdete and Haxhibeqiri, Shpend and Kravic, Nermina and Muminovic Umihanic, Mirnesa and Cima Franc, Ana and Jaksic, Nenad and Babic, Romana and Pavlovic, Marko and Warrings, Bodo and Bravo Mehmedbasic, Alma and Rudan, Dusko and Aukst- Margetic, Branka and Kucukalic, Abdulah and Marjanovic, Damir and Babic, Dragan and Bozina, Nada and Jakovljevic, Miro and Sinanovic, Osman and Avdibegovic, Esmina and Agani, Ferid and Dzubur- Kulenovic, Alma and Deckert, J\"{u}rgen and Domschke, Katharina}, year = {2017}, pages = {10}, DOI = {10.1093/ijnp/pyx111}, chapter = {pyx111}, keywords = {CAPS, DNA methylation, MAOA, PTSD, epigenetics}, journal = {International Journal of Neuropsychopharmacology}, doi = {10.1093/ijnp/pyx111}, volume = {111}, issn = {1461-1457}, title = {Monoamine Oxidase A Gene Methylation and Its Role in Posttraumatic Stress Disorder: First Evidence from the South Eastern Europe (SEE)- PTSD Study}, keyword = {CAPS, DNA methylation, MAOA, PTSD, epigenetics}, chapternumber = {pyx111} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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