Naslov
Whole‐cell asymmetric reduction of prochiral ketones in natural deep eutectic solvents

Autori
Košpić, Karla ; Marin, Petra ; Gukov, Ana ; Panić, Manuela ; Pavoković, Dubrvko ; Delač, Doris ; Cvjetko Bubalo, Marina ; Radojčić Redovniković, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of XII Meeting of Young Chemical Engineers 2018 / - , 2018, 113-113

Skup
XII Meeting of Young Chemical Engineers 2018

Mjesto i datum
Zagreb, Hrvatska, 22.02.2018. - 23.02.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
asymmetric reduction ; natural deep eutectic solvents ; whole-cell biocatalysis

Sažetak
Optically active chiral building blocks are widely used as intermediates in the production of drugs, organic chemicals and agricultural chemicals. As the conventional, environmentally hazardous chemical synthesis is expensive and extremely complicated, there was a rising need to introduce environmentally friendly approaches into the preparation of various commercial products. Herein, two tools of green chemistry were used: performing reactions by biocatalysis and use of alternative green solvents – natural deep eutectic solvents (NADES). For that purpose, due to stereoselectivity of the plant and yeast enzymes, two plant callus cultures - sugar beet and cactus, and baker's yeast Saccharomyces cerevisiae were used as biocatalysts for the asymmetric reduction of 3- methylacetophenone, 3, 4-dimethylacetophenone and 2, 4, 6- trimethylacetophenone into corresponding optically active phenyl-ethanol in choline chloride-based NADES. In summary, we successfully developed an eco- friendly enantioselective reduction in cholinium-based NADES. However, the impact of NADES on whole- cell biocatalysis cannot be simply explained by a single interpretation involving a complicated interaction between them.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA