Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 929147

NKp46 Receptor-Mediated Interferon-g Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.

Glasner, A; Levi, A; Enk, J; Isaacson, B; Viukov, S; Orlanski, S; Scope, A; Neuman, T; Enk, CD; Hanna, JH et al.
NKp46 Receptor-Mediated Interferon-g Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis. // Immunity, 48 (2018), 107-119 doi:10.1016/j.immuni.2017.12.007 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 929147 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
NKp46 Receptor-Mediated Interferon-g Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.

Autori
Glasner, A ; Levi, A ; Enk, J ; Isaacson, B ; Viukov, S ; Orlanski, S ; Scope, A ; Neuman, T ; Enk, CD ; Hanna, JH ; Sexl, V ; Jonjić, Stipan ; Seliger, B ; Zitvogel, L ; Mandelboim, O

Izvornik
Immunity (1074-7613) 48 (2018); 107-119

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
FN1 ; IFN-γ ; NKp46 ; Ncr1 ; RCM imaging ; tumor metastases

Sažetak
Natural killer (NK) cells are innate lymphoid cells, and their presence within human tumors correlates with better prognosis. However, the mechanisms by which NK cells control tumors in vivo are unclear. Here, we used reflectance confocal microscopy (RCM) imaging in humans and in mice to visualize tumor architecture in vivo. We demonstrated that signaling via the NK cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-γ (IFN-γ) secretion from intratumoral NK cells. NKp46- and Ncr1-mediated IFN-γ production led to the increased expression of the extracellular matrix protein fibronectin 1 (FN1) in the tumors, which altered primary tumor architecture and resulted in decreased metastases formation. Injection of IFN-γ into tumor-bearing mice or transgenic overexpression of Ncr1 in NK cells in mice resulted in decreased metastasis formation. Thus, we have defined a mechanism of NK cell- mediated control of metastases in vivo that may help develop NK cell-dependent cancer therapies.

Izvorni jezik
Engleski



POVEZANOST RADA

Projekti:
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Stipan Jonjić (autor)

Avatar Url Mladen Glasner (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Glasner, A; Levi, A; Enk, J; Isaacson, B; Viukov, S; Orlanski, S; Scope, A; Neuman, T; Enk, CD; Hanna, JH et al.
NKp46 Receptor-Mediated Interferon-g Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis. // Immunity, 48 (2018), 107-119 doi:10.1016/j.immuni.2017.12.007 (međunarodna recenzija, članak, znanstveni)
Glasner, A., Levi, A., Enk, J., Isaacson, B., Viukov, S., Orlanski, S., Scope, A., Neuman, T., Enk, C. & Hanna, J. (2018) NKp46 Receptor-Mediated Interferon-g Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.. Immunity, 48, 107-119 doi:10.1016/j.immuni.2017.12.007.
@article{article, author = {Glasner, A and Levi, A and Enk, J and Isaacson, B and Viukov, S and Orlanski, S and Scope, A and Neuman, T and Enk, CD and Hanna, JH and Sexl, V and Jonji\'{c}, Stipan and Seliger, B and Zitvogel, L and Mandelboim, O}, year = {2018}, pages = {107-119}, DOI = {10.1016/j.immuni.2017.12.007}, keywords = {FN1, IFN-γ, NKp46, Ncr1, RCM imaging, tumor metastases}, journal = {Immunity}, doi = {10.1016/j.immuni.2017.12.007}, volume = {48}, issn = {1074-7613}, title = {NKp46 Receptor-Mediated Interferon-g Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.}, keyword = {FN1, IFN-γ, NKp46, Ncr1, RCM imaging, tumor metastases} }
@article{article, author = {Glasner, A and Levi, A and Enk, J and Isaacson, B and Viukov, S and Orlanski, S and Scope, A and Neuman, T and Enk, CD and Hanna, JH and Sexl, V and Jonji\'{c}, Stipan and Seliger, B and Zitvogel, L and Mandelboim, O}, year = {2018}, pages = {107-119}, DOI = {10.1016/j.immuni.2017.12.007}, keywords = {FN1, IFN-γ, NKp46, Ncr1, RCM imaging, tumor metastases}, journal = {Immunity}, doi = {10.1016/j.immuni.2017.12.007}, volume = {48}, issn = {1074-7613}, title = {NKp46 Receptor-Mediated Interferon-g Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.}, keyword = {FN1, IFN-γ, NKp46, Ncr1, RCM imaging, tumor metastases} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.