Naslov
First detection of Zika virus infection in a Croatian traveler returning from Brazil, 2016

Autori
Vilibić-Cavlek, Tatjana ; Betica-Radić, Ljiljana ; Venturi, Giulietta ; Fortuna, Claudia ; Djuričić, Stjepan ; Salvia-Milos, Antonella ; Tabain, Irena ; Barbić, Ljubo ; Stevanović, Vladimir ; Listes, Eddy ; Savini, Giovanni

Izvornik
Journal of Infection in Developing Countries (1972-2680) 11 (2017), 8; 662-667

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Zika virus ; Imported ; Croatia

Sažetak
In the last few years, several imported cases of Zika virus (ZIKV) infection were reported in European countries. We report the first imported ZIKV infection case in a Croatian traveler returning from Brazil. The patient presented with a low-grade fever, pruritic rash, general weakness, myalgia, arthralgia and edema of the legs and recovered completely within a week. ZIKV infection was confirmed by detection of IgM/IgG antibodies using enzyme- linked immunosorbent assay (ELISA) and confirmed by plaque-reduction neutralization test (PRNT). ZIKV IgM antibodies cross-reacted with dengue virus (DENV), West Nile virus (WNV) and tick-borne encephalitis virus (TBEV) in ELISA. In indirect immunofluorescence assay (IFA), IgM cross-reactivity was found only with DENV-3. ZIKV IgG antibodies cross-reacted with DENV in both ELISA and IFA. PRNT for DENV was negative. Control serology performed on days 64 and 98 after disease onset showed a decline in cross-reactive heterologous DENV IgG antibodies compared to persistently high titer of homologous ZIKV IgG antibodies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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