Naslov
Antimicrobial activity of quaternary 3- hydroxyquinuclidinium salts with long alkyl chains

Autori
Bazina, Linda ; Soldo, Barbara ; Maravić, Ana ; Primožič, Ines ; Šprung, Matilda ; Odžak, Renata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Simpozij studenata doktorskih studija PMF-a / Primožič, Ines - Zagreb : Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2018, 35-35

ISBN
978-953-6076-43-7

Skup
2. simpozij studenata doktorskih studija PMF-a

Mjesto i datum
Zagreb, Hrvatska, 09.02.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Quaternary ammonium salts, antimicrobial activity

Sažetak
Quinuclidine, bicyclic alkaloid, easily forms quaternary ammonium compounds (QACs) which exhibit diverse biological and pharmacological activity. Given their amphiphilic nature, cationic part of salts electrostatically interacts with the negatively charged phospholipids of the bacterial cell wall so that long alkyl tails of salts can penetrate into the membrane of bacteria. [1] In order to explore antimicrobial activity we have synthesized quaternary 3- hydroxyquinuclidinium salts with different lengths of alkly chains (C10, C12 and C14). Compounds were acquired in significant yields and their structures were affirmed by 1H NMR, 13C NMR and IR spectral data. The antimicrobial activity was tested against Gram-positive, Gram-negative bacteria both ATCC and clinical isolates as well against fungal strains, using broth microdiluton method to determine minimum inhibitory concentrations (MICs). Activity toward inhibition of the biofilm structures was also tested. Our preliminary results indicate that the tested compounds have a better activity against Gram-positive bacteria and the compound displaying the highest antibacterial activity is the one with the longest alkyl chain.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA