Naslov
Highly fluorescent biologically active iminocoumarines with interesting spectroscopic properties

Autori
Cindrić, Maja ; Perin, Nataša ; Starčević, Kristina ; Maurić, Maja ; Liekens, Sandra ; Hranjec, Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts, Central European Conference on Photochemistry CECP 2018, Bad Hofgastein, Austria, 4.-8.02.2018. / - , 2018, 50-50

Skup
Central European Conference on Photochemistry (CECP 2018)

Mjesto i datum
Bad Hofgastein, Austrija, 04.02.2018. - 08.02.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
iminocoumarines, pH titrations, chemosensors, antioxidative activity, antitumor activity

Sažetak
The coumarin derivatives have been one of the most widely studied classes of fluorescent dyes and probably one of the most frequently used fluorescent compounds. Fluorescent coumarin derivatives have been widely used in many applications from cell biology, medical analysis, lasers, sensors, to the advanced photophysical systems [1]. This work presents the synthesis of iminocoumarine derivatives as a potential biologically active agents. Their molecular structure incorporate a push-pull functionality, the N, N-dialkylamino group at the 7-position is an electron donor, while an electron withdrawing group, such as benzimidazole, benzothiazole and imidazopyridine fragment at the 3-position, enhances the fluorescence efficiency. The spectroscopic properties of these compounds were evaluated in several polar and non-polar organic solvents. pH titrations were carried out to explore their potential as chemosensors and pH probes. Antioxidative potency has been evaluated by in vitro spectrophotometric assays and antitumor activity in vitro was tested on three human tumour cell lines [2, 3].

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA