Pregled bibliografske jedinice broj: 917524
Halohydrin dehalogenase-catalysed transformations of epifluorohydrin
Halohydrin dehalogenase-catalysed transformations of epifluorohydrin // Tetrahedron letters, 59 (2018), 4; 406-408 doi:10.1016/j.tetlet.2017.12.054 (međunarodna recenzija, članak, znanstveni)
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Naslov
Halohydrin dehalogenase-catalysed transformations
of epifluorohydrin
Autori
Majerić Elenkov, Maja ; Čičak, Mirjana ; Knežević, Anamarija ; Smolko, Ana
Izvornik
Tetrahedron letters (0040-4039) 59
(2018), 4;
406-408
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Biocatalysis ; Halohydrin dehalogenase ; Epoxide ring-opening ; Epifluorohydrin ; Fluoro alcohols
Sažetak
Biocatalytic ring-opening of epifluorohydrin has been performed by using halohydrin dehalogenase. The enzyme from Mycobacterium sp. GP1 (HheB2) catalysed reaction with high regioselectivity and low enantioselectivity in the presence of different nucleophiles, producing racemic 1- substituted 3-fluoro-2- propanols. No by-products resulting from the ring-closure reaction have been detected, confirming that vicinal fluoro alcohols are not substrates for HHDH. Four different 3- fluoro-2- propanols were prepared under mild reaction conditions starting from epifluorohydrin. High conversions of 85-100% were reached within 1- 3h and depending on the nucleophile used products were isolated in 31-92% yields.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
Napomena
Reaxys ; Current Contents Search ; Derwent Drug File
; Pascal ; Research Alert ; SciSearch
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Strojarski fakultet, Slavonski Brod
Profili:
Mirjana Čičak
(autor)
Ana Smolko
(autor)
Anamarija Knežević
(autor)
Maja Majerić Elenkov
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Arts & Humanities Citation Index (A&HCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
Uključenost u ostale bibliografske baze podataka::
- BIOSIS Previews (Biological Abstracts)
- CAB Abstracts
- CA Search (Chemical Abstracts)
- Chemical Engineering and Biotechnology Abstracts
- Compendex (EI Village)
- Current Biotechnology Abstracts
- EMBASE (Excerpta Medica)
- Reaxys
- Current Contents Search
- Derwent Drug File
- Pascal
- Research Alert
- SciSearch
