Naslov
CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential

Autori
Bišćanin, Alen ; Ljubičić, Neven ; Boban, Marko ; Baličević, Drinko ; Pavić, Ivana ; Maver-Bišćanin, Mirela ; Budimir, Ivan ; Dorošulić, Zdravko ; Duvnjak, Marko

Izvornik
Anticancer research (0250-7005) 36 (2016), 10; 5437-5442

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Connexin 43 ; colorectal cancer ; adenomatous polyp

Sažetak
Colorectal cancer is a major public health problem. The adenoma-carcinoma sequence offers potential for screening and surveillance. We tested the clinical behavior and diagnostic utility of connexin 43 (CX43) in connection with pathohistological risk. Immunohistochemical expression of CX43 in colonic adenomas and surrounding mucosa from 87 patients was determined. CX43 expression was higher in mucosa surrounding adenomas with high-grade dysplasia (p=0.047), larger adenomas (p=0.015) and villous adenomas (p=0.02). No difference of CX43 expression in adenomas according to grade of dysplasia was found (p=0.87). CX43 expression in adenomas was dependent on the patient's hemoglobin level (p=0.002), family history of colorectal cancer (p=0.009) and statin therapy (p=0.049). CX43 expression in mucosa surrounding adenoma could be an additional factor indicative of malignant potential. CX43 expression in colonic adenoma seems to be closely related to family history of colorectal cancer, statin therapy and hemoglobin level.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA