Pregled bibliografske jedinice broj: 916725
Osteopontin expressing macrophages predict survival in diffuse large B cell lymphoma
Osteopontin expressing macrophages predict survival in diffuse large B cell lymphoma // Virchows Archiv (2017) 471 (Suppl 1):S1–S352 / Massi ; Daniela (ur.).
Heidelberg: Springer, 2017. str. S143-S143 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 916725 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Osteopontin expressing macrophages predict
survival in diffuse large B cell lymphoma
Autori
Lučin, Ksenija ; Pupić Bakrač, Petra ; Šore, J ; Stanić, M ; Valković, Toni ; Duletić- Načinović, Antica ; Hadžisejdić, Ita ; Jonjić, Nives
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Virchows Archiv (2017) 471 (Suppl 1):S1–S352
/ Massi ; Daniela - Heidelberg : Springer, 2017, S143-S143
Skup
29th European Congress of Pathology
Mjesto i datum
Amsterdam, Nizozemska, 02.09.2017. - 06.09.2017
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Osteopontin ; tumour associated macrophages ; diffuse large B-cell lymphoma ; prognosis
Sažetak
Objective: Osteopontin (OPN) is cell adhesion molecule and cytokine expressed by many tumour cells as well as tumour associated macrophages (TAMs). The aim of this pilot study was to analyse the prognostic significance of osteopontin expressed by TAMs in patients with diffuse large B-cell lymphoma (DLBCL). Method: The expression of osteopontin in TAMs was analyzed immunohistochemically on tissue microarrays of 81 DLBCLs. OPN expression was scored semiquantitatively as low, moderate or strong. The level of OPN expression in TAMs was correlated with clinicopathological data and overall patient’s survival. Results: Low OPN expression was found in 32 cases (40 %), moderate in 31 (38 %) and strong in 18 cases (22 %). High level of OPN expression in TAMs was associated with increased international prognostic index (p < 0.001) and high serum LDH level. There was a trend toward the association of low OPN level and complete response to therapy (p < 0.06). Also, higher level of OPN expression in TAMs was associated with poor overall survival (p < 0.04). Conclusion: OPN expressed by TAMs is potential prognostic factor in DLBCL patients.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
Fakultet zdravstvenih studija u Rijeci
Profili:
Antica Duletić-Načinović
(autor)
Toni Valković
(autor)
Ksenija Jurinović
(autor)
Ita Hadžisejdić
(autor)
Nives Jonjić
(autor)