Differences in neurohumoral and hemodynamic response to prolonged head-up tilt between patients with high and normal standing norepinephrine forms of postural orthostatic tachycardia syndrome

Crnošija, Luka; Krbot Skorić, Magdalena; Lovrić, Mila; Junaković, Anamari; Miletić, Vladimir; Šprljan Alfirev, Rujana; Pavelić, Antun; Adamec, Ivan; Habek, Mario

doi:10.1016/j.autneu.2017.05.007

Pregled bibliografske jedinice broj: 915784

Differences in neurohumoral and hemodynamic response to prolonged head-up tilt between patients with high and normal standing norepinephrine forms of postural orthostatic tachycardia syndrome

Crnošija, Luka; Krbot Skorić, Magdalena; Lovrić, Mila; Junaković, Anamari; Miletić, Vladimir; Šprljan Alfirev, Rujana; Pavelić, Antun; Adamec, Ivan; Habek, Mario

Differences in neurohumoral and hemodynamic response to prolonged head-up tilt between patients with high and normal standing norepinephrine forms of postural orthostatic tachycardia syndrome // Autonomic neuroscience: basic & clinical, 205 (2017), 110-114 doi:10.1016/j.autneu.2017.05.007 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 915784 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Differences in neurohumoral and hemodynamic response to prolonged head-up tilt between patients with high and normal standing norepinephrine forms of postural orthostatic tachycardia syndrome

Autori
Crnošija, Luka ; Krbot Skorić, Magdalena ; Lovrić, Mila ; Junaković, Anamari ; Miletić, Vladimir ; Šprljan Alfirev, Rujana ; Pavelić, Antun ; Adamec, Ivan ; Habek, Mario

Izvornik
Autonomic neuroscience: basic & clinical (1566-0702) 205 (2017); 110-114

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Dopamine ; Epinephrine ; High standing NE ; Norepinephrine ; Postural orthostatic tachycardia syndrome

Sažetak
Objective was to investigate the optimal timing for blood sample collection of catecholamines and the possible correlations between neurohumoral and hemodynamic responses to prolonged head-up tilt (HUT) in postural orthostatic tachycardia syndrome (POTS). Nineteen patients underwent a 30-minute, 70° HUT test. Blood samples (norepinephrine (NE), epinephrine and dopamine) were taken in the 10th minute of supine, and 10th, 20th and 30th minutes of HUT. There were no significant differences in the proportion of high and normal standing NE patients in the different time points. Mean NE (nmol/L) values in 10th, 20th and 30th minute of HUT were 4.37, 4.87, and 4.35 in the high standing NE, and 2.49, 2.59 and 2.88 in the normal standing NE group. High standing NE patients had higher blood pressure (BP) during the first 6min of HUT (2nd minute after the HUT systolic BP (sBP): 118.29±15.65 vs. 95.70±13.43, p=0.004 ; diastolic BP (dBP): 78.71±6.68 vs. 65.10±9.04, p=0.003), while normal standing NE patients exhibited a drop in BP compared to resting values during the same time period. The normal standing NE group exhibited a progressive increase in norepinephrine values during the HUT. One blood sample taken at the 10th minute of HUT correctly identifies high and normal standing NE POTS patients, but a small number of patients (1 out of 19, 5.2%) can be misidentified. High and normal standing NE POTS patients display distinctly different neurohumoral and hemodynamic responses to HUT.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Interdisciplinarne biotehničke znanosti

POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Mario Habek (autor)