Naslov
QuantiFERON-TB Gold In-Tube TEST IN THE DIAGNOSIS OF LATENT TUBERCULOSIS INFECTION IN ARTHRITIS PATIENTS TREATED WITH TUMOR NECROSIS FACTOR ANTAGONISTS

Autori
Baričević, Denis ; Popović-Grle, Sanja ; Morović Vergles, Jadranka ; Čuković Čavka, Silvija ; Jakopović, Marko ; Gzim, Redžepi ; Boras, Zagorka ; Baričević, Marinka ; Samaržija, Miroslav

Izvornik
Acta clinica Croatica (0353-9466) 56 (2017); 203-209

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Tuberculin test ; Latent tuberculosis – diagnosis ; Arthritis ; Tumor necrosis factors – antagonists and inhibitors ; Biological therapy ; Croatia

Sažetak
Th e aim of this study was to investigate the role of the QuantiFERON-TB Gold In-Tube test (QFT-GIT) in detecting latent tuberculosis in immunocompromised patients before introducing tumor necrosis factor (TNF-α) antagonists. Th e study included 300 subjects of similar age. Th e study group comprised of 150 QuantiFERON (QFT) positive subjects with rheumatoid arthritis, Crohn’s disease, ulcerative colitis, ankylosing spondylitis and psoriatic arthritis, while control group comprised of 150 QFT negative respondents with the same diseases. Exhaustive medical history was documented for all patients. Screening tests were performed including QFT-GIT, tuberculin skin test (TST), chest radiography and detection of Mycobacterium tuberculosis in sputum culture 2 times. A positive QFT-GIT test result, regardless of TST result, was considered as an indication for latent tuberculosis infection (LTBI) treatment. Results of this study showed good correlation between the conclusive results of QFT-GIT and TST. All study group patients had normal clinical fi ndings, normal radiologic fi ndings and negative results of sputum microbiological analysis during the course of prophylaxis and after its completion and during the course of biological therapy. Conversion of positive QFT-GIT test to negative was observed in 4% of study group patients, while QFT negative respondents remained negative. Th ere was a statistically signifi cant positive correlation between QFTGIT, TST results and patient age, smoking habit and contact with tuberculosis. Study results showed that along with good clinical evaluation and detailed medical history, it is important to conduct testing in order to avoid disease progression or unnecessary isoniazid prophylaxis

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA