Naslov
Cell-mediated cytotoxicity in experimental cholestasis

Autori
Mrakovčić-Šutić, Ines ; Čuka-Husnjak, Smiljana ; Dvornik, Štefica ; Radošević-Stašić, Biserka ; Rukavina, Daniel

Izvornik
Toxicology letters (0378-4274) (2002), Suppl.1;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
cholestasis; NK and NKT-cell mediated cytotoxicity; liver

Sažetak
The data have shown that early after common bile duct ligation intrahepatic and splenic MNLC became more cytotoxic to YAC-1 (NK sensitive) and to P815 (LAK sensitive) targets. These effects correlated with the increased proportion of NK cells in the liver. Simultaneously, in the liver increased also the proportion of NKT cells (T cell receptor intermediate (TCRint) cells, NK1.1+ and IL-2Rbeta+), which as autoreactive cells, contributed to enhanced cytotoxicity of intrahepatic MNLC against syngeneic thymocytes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA