Pregled bibliografske jedinice broj: 907142
Environmental and metabolic therapeutic strategies improve anxiety-related behaviour in a rat model of sporadic Alzheimer’s disease
Environmental and metabolic therapeutic strategies improve anxiety-related behaviour in a rat model of sporadic Alzheimer’s disease // Abstracts of the WASAD Conference 2017, 14–16 September, Würzburg, Germany
Beč: Springer, 2017. str. 1303-1304 doi:10.1007/s00702-017-1777-9 (predavanje, nije recenziran, sažetak, znanstveni)
CROSBI ID: 907142 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Environmental and metabolic therapeutic strategies improve anxiety-related behaviour in a rat model of sporadic Alzheimer’s disease
Autori
Homolak, Jan ; Osmanović Barilar, Jelena ; Babić, Ana ; Knezović, Ana ; Riederer, Peter ; Šalković- Petrišić, Melita
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstracts of the WASAD Conference 2017, 14–16 September, Würzburg, Germany
/ - Beč : Springer, 2017, 1303-1304
Skup
International Congress of the World Association for Stress Related and Anxiety Disorders (WASAD)
Mjesto i datum
Würzburg, Njemačka, 14.09.2017. - 16.09.2017
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
streptozotocin ; Alzheimer's disease ; anxiety ; galactose
Sažetak
Objectives Literature data indicate that physical and mental activities have beneficial effects on cognitive impairments in Alzheimer’s disease (AD), while our previous results suggest possible beneficial effect of galactose treatment in sAD animal model, streptozotocin- intracerebroventricularly (STZ-icv) treated rats. We investigated whether the long-term enriched housing and galactose treatment could improve learning and memory deficits and anxiety found in this sAD animal model. Methods Adult male Wistar rats were given STZ-icv (3 mg/kg) while controls received vehicle only. One group received oral galactose treatment (200 mg/kg) 4 month after icv injections and continued for 2 months on daily basis until sacrifice. The other group was rendered for 9 weeks to enriched housing (EH) 3 weeks after STZ-icv treatment. Behavioural assessment was done by Morris Water Maze Swimming (MWM) test, Dry maze (DM) and Open field test (OF). Data were analysed by Kruskal-Wallis and Mann- Whitney U-test (p<0.05). Result Significant deficit in learning and memory functions was found 3 (-31%, MWM) and 6 (+58%, MWM) month after STZ-icv treatment, in comparison to the controls, and increased anxiety (+142%, DM and +395%, OF, respectively). Changes in anxiety were normalised in rats subjected to EH and galactose treatment, while only EH normalised learning and memory deficit. Conclusion Results indicate that intensive and long-term mental activity and galactose treatment alleviates anxiety-like behaviour in STZ-icv rat model of sAD, while cognitive improvement depends on the start of the treatment after the STZ-icv injection that might depend on irreversible changes found previously in later stages of AD in this model. Supported by MZOS (108-1080003-0020), DAAD and HRZZ-IP-2014-09-4639.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
DAAD
--IP-2014-09-4639 - TERAPIJSKI POTENCIJAL ORALNE GALAKTOZE U EKSPERIMENTALNOJ ALZHEIMEROVOJ BOLESTI (GALAD) (Melita Šalković, Petrišić) ( CroRIS)
MZOS-108-1080003-0020 - Mozak, eksperimentalni i cerebralni dijabetes i kognitivni i drugi poremećaji (Šalković-Petrišić, Melita, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Jan Homolak
(autor)
Melita Šalković-Petrišić
(autor)
Ana Babić Perhoč
(autor)
Ana Knezović
(autor)
Jelena Osmanović
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE