Naslov
Possible protective effects of docosahexaenoic acid (DHA) in combined prenatal exposure to methylmercury and long chain polyunsaturated fatty acids (LCPUFA)

Autori
Radić Nišević, Jelena ; Prpić, Igor ; Vukelić, Petar ; Špirić, Zdravko ; Horvat, Milena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Paediatric Neurology Volume 21, Supplement 1, Pages e1-e254 (June 2017) / - Lyon : European Paediatric Neurology Society, 2017, E68-e68

Skup
12th European Paediatric Neurology Society Congress

Mjesto i datum
Lyon, Francuska, 20.06.2017. - 24.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Prenatal exposure, long-chain, polyunsaturated fatty acids

Sažetak
Objective: Prenatal exposure to long-chain polyunsaturated fatty acids (LCPUFA) is essential for normal fetal growth and neurodevelopment. Availability of LCPUFA depends mostly on maternal fish consumption which also exposes the fetus to the methylmercury (MeHg). MeHg is neurotoxicant whose prenatal low-level can affect long-term child neurodevelopment, which are considered to be mediated by oxidative damage and consequently inflammation. However, the impact of combined LCPUFA and MeHg from fish consumption during pregnancy may lead to contradictory influences on child development outcomes. Depending on which particular LCPUFA are present in the diet, neuroinflammation will, therefore, be kept at a minimum or exacerbated. We hypothesized that prenatal exposure LCPUFA through mother's consumption of fish can overcome or mask the effect of prenatal exposure to MeHg which would have potential protective effects in children with higher levels of MeHg.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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