Naslov
Predisposing factors for metabolic syndrome in pregnancy and newborns` body size: preliminary report from the CRoatian Islands` Birth Cohort Study

Autori
Havaš Auguštin, Dubravka ; Zajc Petranović, Matea ; Šarac, Jelena ; Carić, Tonko ; Perinić Lewis, Ana ; Novokmet, Natalija ; Pribačić Ambrožić, Vanda ; Sindik, Joško ; Čoklo, Miran ; Karelović, Deni ; Škrabić, Veselin ; Žižić, Ana ; Stanišić, Lada ; Orehovec, Biserka ; Romić, Željko ; Janković, Stipan ; Cameron, Noel ; Demerath, Ellen ; Schell Lawrence ; Missoni, Saša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Developmental Origins of Health and Disease. 10th World Congress 15-18 October 2017 Rotterdam, The Netherlands / Jaddoe, W.V. - : Cambridge University Press, 2017, S75-S76

Skup
10th World Congress on Developmental Origins of Heatht and Disease

Mjesto i datum
Rotterdam, Nizozemska, 15.10.2017. - 18.10.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
birth cohort, CRIBS, metabolic syndrome, pregnancy, newborns, Croatia

Sažetak
The prevalence of Metabolic Syndrome (MetS) on Eastern Adriatic islands is higher than in neighboring mainland area. The CRoatian Islands` Birth Cohort Study (CRIBS) is an ongoing 3-year-project with an aim to assess the prevalence of known risk factors for MetS. The CRIBS sample consists of pregnant women from Dalmatian islands Brač and Hvar and nearby coastal town Split and its surroundings, who had no history of chronic diseases (particularly MetS), who conceived naturally and had singleton pregnancies, and their newborns. We tested the association of possible predisposing factors for MetS (age, smoking, prepregnancy BMI, fasting blood biochemical parameters) and newborns` anthropometric measures. In this preliminary sample (n=131, age range 19.8-41.7 yrs, mean 30.6±4.6 yrs), 28.3% of women reported smoking in pregnancy and 22.2% reported being exposed to passive smoking. 17.9% of all the women were overweight and 4.7% were obese. In comparison to underweight women (<18.5 kg/m2), obese pregnant women gave birth to heavier (p<0.05) and taller babies (p<0.01). Newborns of primi- and multiparous mothers were significantly taller (p<0.05) and had bigger head circumference (p<0.001) than newborns of nulliparous mothers. Women with higher mean triglyceride levels more often had large for gestational age than normal for gestational age children (p<0.01). Smokers, in comparison to non-smokers, had significantly higher triglycerides (p<0.05) and lower HDL cholesterol (p<0.01). All the predisposing factors for MetS were compared according to the island and mainland place of residence: newborns` size at birth (weight, length and head circumference, z-standardized according to WHO) did not differ between the two groups. The only difference was detected in women ; islanders had higher glucose (p<0.05), while women from the mainland had higher homocysteine and lipoprotein(a) (both p<0.05). Despite none of the investigated women was diagnosed with MetS, some of its components have a considerable prevalence in the investigated CRIBS population.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

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