Pregled bibliografske jedinice broj: 898835
Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility
Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility // Journal of global antimicrobial resistance, 10 (2017), 213-218 doi:10.1016/j.jgar.2017.07.001 (podatak o recenziji nije dostupan, članak, znanstveni)
CROSBI ID: 898835 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility
Autori
Ladavac, Ranko ; Bedenić, Branka ; Vranić- Ladavac, Mirna ; Barišić, Nada ; Karčić ; Pompe, Natalie Karoline ; Ferenčić, Antun ; Stojanović, Aleksandar ; Seifert, Harald ; Katić, Stjepan ; Higgins, Paul G.
Izvornik
Journal of global antimicrobial resistance (2213-7165) 10
(2017);
213-218
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Acinetobacter baumannii, Carbapenems, Carbapenem-hydrolyzing oxacillinaseResistance
Sažetak
During routine diagnostic laboratory work, the clinical microbiologist observed an increase of Acinetobacter baumannii isolates with three different carbapenem susceptibility patterns: susceptible, intermediate and resistant. Isolates belonging to the same carbapenem susceptibility phenotype exhibited identical susceptibility/resistance patterns to non-β-lactam antibiotics. This prompted us to analyse the mechanisms of carbapenem-resistance and the molecular epidemiology of the isolates. A total of 59 A. baumannii isolates were analysed and grouped according to their susceptibility to imipenem: group 1 were susceptible (N=24), group 2 were intermediate (N=8) and group 3 were resistant (N=27) to imipenem. PCR and sequencing was used to detect resistance genes. Genotyping of the isolates was performed by PFGE and MLST. Out of 27 resistant isolates, 20 harboured blaOXA-40-like and 7 blaOXA-23-like genes. ISAba1 was found upstream of blaOXA-51 and blaOXA-23 genes. PFGE genotyping demonstrated the existence of three major A. baumannii clones in GH Pula and determination of sequence groups showed that the isolates belonged to international clones commonly associated with multidrug-resistance. MLST (performed on six isolates) showed diverse population structure of isolates belonging to the same cluster, including ST 195, ST 231, ST 775 and ST 1095. A previous study conducted in 2009-2010 showed that reduced susceptibility to carbapenems in GH Pula was only associated with upregulation of the intrinsic OXA-51 β-lactamase. In this study a shift to isolates with acquired oxacillinases, belonging to two major clones was reported. Copyright © 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Hrvatski zavod za javno zdravstvo,
Medicinski fakultet, Rijeka,
Medicinski fakultet, Zagreb,
Opća bolnica Pula,
Klinički bolnički centar Zagreb
Profili:
Mirna Vranić-Ladavac
(autor)
Antun Ferenčić
(autor)
Branka Bedenić
(autor)
Stjepan Katić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE