Pregled bibliografske jedinice broj: 897205
Hypopituitarism after gamma knife radiosurgery for pituitary adenoma
Hypopituitarism after gamma knife radiosurgery for pituitary adenoma // Endocrine research, 42 (2017), 4; 318-324 doi:10.1080/07435800.2017.1323913 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 897205 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Hypopituitarism after gamma knife radiosurgery for pituitary adenoma
Autori
Zibar Tomšić, Karin ; Dušek, Tina ; Kraljević, Ivana ; Heinrich, Zdravko ; Solak, Mirsala ; Vučinović, Ana ; Ozretić, David ; Mihailović Marasanov, Sergej ; Hršak, Hrvoje ; Kaštelan, Darko
Izvornik
Endocrine research (0743-5800) 42
(2017), 4;
318-324
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Hypopituitarism ; Gamma knife ; Radiosurgery ; Pituitary adenoma
Sažetak
The aim of the study was to investigate the incidence of and risk factors for hypopituitarism after gamma knife radiosurgery (GKRS) for pituitary adenoma. We conducted a retrospective analysis of the pituitary function of 90 patients who underwent GKRS for pituitary adenoma at the University Hospital Centre Zagreb between 2003 and 2014. Twenty seven of them met the inclusion criteria and the others were excluded from the study due to pituitary insufficiency which was present before GKRS. Eighteen patients had non- functioning and 9 patients had secretory adenomas. Median patients’ age was 56 years (24–82). GKRS was performed using the Leksell gamma knife Model C. The median prescription radiation dose was 20 Gy (15–25) and the median tumor volume size was 3.4 cm3 (0.06–16.81). New onset hypopituitarism was defined as a new deficit of one of the three hormonal axes (corticotroph, thyreotroph, or gonadotroph) ≥3 months following GKRS. SPSS was used for statistical analysis, with the significance level at P<0.05. During the median follow-up period of 72 months (range 6–144), 30% of patients developed new hypopituitarism after GKRS. This corresponds to incidence of one new case of hypopituitarism per 15 patient- years. Age, gender, tumor function, tumor volume, suprasellar extension, prescription dose of radiation, as well as dose-volume to the pituitary gland, stalk and hypothalamus were not predictive factors for the development of hypopituitarism. In our cohort of patients with pituitary tumors who underwent GKRS, 30% developed new hypopituitarism during the follow-up period.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Klinička bolnica "Merkur",
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac,
Medicinski fakultet, Zagreb,
KBC Split,
Klinički bolnički centar Zagreb
Profili:
Darko Kaštelan
(autor)
Tina Dušek
(autor)
Hrvoje Hršak
(autor)
Zdravko Heinrich
(autor)
David Ozretić
(autor)
Ivana Kraljević
(autor)
Karin Zibar Tomšić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE