Naslov
Mechanical and in-vitro performance of porous hydroxyapatite/poly(lactic acid)/polycaprolactone composite scaffolds

Autori
Ivanković, Hrvoje ; Rogina, Anamarija ; Milovac, Dajana ; Gloria, Gallego Ferrer ; Ivanković, Marica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
The International Journal of Artificial Organs / Remuzzi, Andrea ; Stegmayr, Bernd - Beč : Wichtig Publishing, 2017

Skup
ESAO-IFAO Congress, 2017

Mjesto i datum
Beč, Austrija, 06.09.2017. - 09.09.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Hydroxyapatite, PCL, PLA, mechanical properties, citotoxicity
(Hdroxyapatite, PCL, PLA, mechanical properties, citotoxicity)

Sažetak
Hydrothermal transformation of aragonitic cuttlefish bone into hydroxyapatite (HAp) was performed while retaining the cuttlebone architecture. Composite structures were obtained using vacuum impregnation technique with different PCL/PLA ratios. Final three-component systems were characterized by X-ray diffraction, FTIR spectroscopy, TGA and SEM. Influence of different polymer ratio on mechanical properties was investigated by compressive test, while cytotoxicity of materials was evaluated by MTS assay. Results X-ray diffraction, FTIR spectroscopy and SEM confirmed thermal conversion of aragonite to HAp maintaining original cuttlefish bone microstructure. Compressive test showed that the PCL/PLA-coated HAp scaffold resulted in a material with improved mechanical properties with interconnected porous structure indispensable for tissue growth and vascularization. Variation of PCL-PLA ratio has resulted in alteration of scaffolds elasticity. Additionally, prepared PCL/PLA-HAp systems are non-cytotoxic.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne tehničke znanosti

POVEZANOST RADA