Naslov
Effect of chirality on conformational properties of ferrocene peptides: synthesis, X- ray crystal structure and DFT study

Autori
Barišić, Lidija ; Kovačević, Monika ; Kovač, Veronika ; Molčanov, Krešimir ; Kodrin, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Solid State Science and Research 2017 : Book of Abstracts / Juribašić Kulcsar, Marina ; Halasz, Ivan - Zagreb : Institut Ruđer Bošković, 2017, 66-66

ISBN
978-953-7941-15-4

Skup
Solid State Science and Research 2017

Mjesto i datum
Zagreb, Hrvatska, 28.06.2017. - 30.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
ferrocene ; peptides ; conformation, ; X-ray ; DFT

Sažetak
Reverse turns are structural features of proteins and peptides in which a polypeptide chain changes its direction enabling a protein to fold back on itself.[1] Besides the role in protein folding, turns are involved in molecular recognition processes.[1, 2] Ferrocene-1, 1'-diamine was established as molecular template for the design of turns in symmetricaly disubstituted derivatives.[3] Herein we report the DFT-predicted effect of the backbone chirality on the solid-state conformational properties of orthogonally protected asymmetric peptides containing homo- (1) and heterochiral (2) amino acids. Also, the crystal structure of the conjugate 1 is determined

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA