Naslov
Adamantanski derivati ferocena: utjecaj na modelne lipidne membrane i antioksidacijska svojstva
(Adamantyl derivatives of ferrocene: their effect on the model lipid membranes and their antioxidant abilities)

Autori
Štimac, Adela ; Lapić, Jasimina ; Blasina, Valentino ; Lukinac, Marija ; Djakovic, Senka ; Crnolatac, Ivo ; Frkanec, Leo ; Frkanec, Ruža

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
25. Hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem ; 3. simpozij Vladimir Prelog : knjiga sažetaka = 25th Croatian Meeting of Chemist and Chemical Engineers with international participation. 3rd symposium “Vladimir Prelog” : Book of Abstracts / Šantić, Ana ; Đaković, Marijana - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo, 2017, 207-207

ISBN
978-953-552327-7

Skup
25. Hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem ; 3. simpozij Vladimir Prelog = 25th Croatian Meeting of Chemist and Chemical Engineers with international participation. 3rd symposium “Vladimir Prelog”

Mjesto i datum
Poreč, Hrvatska, 19.04.2017. - 22.04.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
adamantanski feroceni ; membranska fluidnost ; liposomi ; antioksidansi ; DSC ; fluorescentna anizotropija
(adamantyl ferrocene ; membrane fluidity ; liposomes ; antioxidants ; DSC ; fluorescence anisotropy)

Sažetak
The aim of this study was to design and synthesize new adamantyl derivatives of ferrocene and explore their effects on fluidity of model lipid membranes as well as their antioxidant abilities. Homoannularly and heteroannularly substituted adamantyl derivatives of ferrocene, were synthesized and incorporated into liposomes. Differential scanning calorimetry and fluorescence anisotropy measurements were employed for investigation of membrane fluidity. The liposomes have been described as an artificial model membrane system and are often used for different biochemical and biophysical studies [1, 2]. In our previous investigations dealing with the synthesis of adamantane derivatives and investigations of liposomes as drug delivery systems as well as model membranes we have demonstrated the significance of the interaction of adamantane molecule and phospholipids in lipids bilayer [3- 5]. Recent studies have shown the wide application of ferrocene as a structural feature in organic and medicinal chemistry [5]. The obtained results have shown that the adamantyl derivatives of ferrocene significantly affect the structure of the lipid bilayer and cause decrease in membrane fluidity. The antioxidant potential of synthesized compounds was assessed using DPPH method and it was shown that examined compounds possess considerable antioxidant activity. In conclusion, results of preliminary investigations have demonstrated that the adamantyl derivatives of ferrocene possess certain activities and justify further research of their potential biomedical application.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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