Naslov
Microwave-assisted quaternization of various pyridine derivatives and their antibacterial activity

Autori
Bušić, Valentina ; Pavlović, Hrvoje ; Roca, Sunčica ; Vikić-Topić, Dražen ; Gašo-Sokač, Dajana

Izvornik
Croatica chemica acta (0011-1643) 90 (2017), 3; 425-433

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
mikrovalna sinteza ; derivati piridina ; antibakterijska aktivnost ; NMR ; reakcije kvaternizacije
(microwave synthesis ; pyridine derivatives ; antibacterial activity ; NMR ; quaternization)

Sažetak
In this study, reactions of quaternization under microwave heating of pyridine, α- picoline, pyridine-4-aldoxyime, pyridine-2- aldoxime, nicotinamide, isonicotinamide and pyridoxal oxime with different electrophiles: 2-bromo-4'-nitroacetophenone, 2-amino-4- chloromethylthiazole hydrochloride, methyl iodide, 1, 3-diiodopropane and 1, 3- dibromopropane are reported. The synthesis yield by microwave dielectric heating is improved and reaction time shortened compared to conventional heating. The structure of obtained molecules were analyzed and determined by 1D and 2D NMR spectroscopy methods, IR spectroscopy and mass spectrometry. The highest antibacterial activity against two Gram- positive and two Gram-negative bacteria strains has beeen found for 1-[2-(4-nitrophenyl)-2- oxoethyl]pyridinium bromide (2).

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija

POVEZANOST RADA